Prevalence and Clinical Characteristics of SARS-CoV-2 Confirmed and Negative Kawasaki Disease Patients During the Pandemic in Spain.
Prevalence and Clinical Characteristics of SARS-CoV-2 Confirmed and Negative Kawasaki Disease Patients During the Pandemic in Spain.
复制标题
DOI：
10.3389/fped.2020.617039
复制
发表时间：
2020
影响因子：
2.6
通讯作者：
KAWA-RACE Study Group
中科院分区：
文献类型：
--
作者：
Fernández-Cooke E;Grasa CD;Domínguez-Rodríguez S;Barrios Tascón A;Sánchez-Manubens J;Anton J;Mercader B;Villalobos E;Camacho M;Navarro Gómez ML;Oltra Benavent M;Giralt G;Bustillo M;Bello Naranjo AM;Rocandio B;Rodríguez-González M;Núñez Cuadros E;Aracil Santos J;Moreno D;Calvo C;KAWA-RACE Study Group
导言：COVID-19在儿童中的病程较轻。2020年4月，一些儿童出现多系统炎症症状，临床症状与川崎病（KD）重叠，其中大多数需要入住儿科重症监护病房（PICU）。本研究旨在描述西班牙大流行期间KD SARS-CoV-2确诊和阴性患者的流行情况和临床特征。材料与方法：2018年1月1日至2020年5月30日KD患者的医疗数据收集自KAWA-RACE研究组。我们比较了COVID-19期间（2020年3月1日至5月30日）诊断为SARS-CoV-2确诊（CoV+）或阴性（CoV -）的KD病例与2018年和2019年同期（PreCoV）的病例。结果：共收集病例124例。2020年病例数和PICU入院数显著增加（p趋势分别为0.001和0.0004）。CoV+患者明显年龄较大（7.5 vs. 2.5岁），主要是非高加索人（64 vs. 29%）， KD表现不完全（73 vs. 32%），白细胞（9.5 vs. 15.5 × 109）和血小板计数（174 vs. 423 × 109/L）较低，炎症标志物（c反应蛋白18.5vs. 423 × 109/L）较高。10.9 mg/dl)和利钠性心房肽末端段（4,766 vs 505 pg/ml），动脉瘤发展较少（3.8 vs 11.1%），心肌功能障碍较多（30.8 vs 1.6%）。在COVID-19期间，呼吸道症状未增加。结论：KD冠状病毒阳性患者多符合小儿炎症性多系统综合征暂时伴发COVID-19/儿童多系统炎症综合征标准。这究竟是一种新的疾病，还是同一种疾病在不同的极端，目前还不清楚。
Introduction: COVID-19 has a less severe course in children. In April 2020, some children presented with signs of multisystem inflammation with clinical signs overlapping with Kawasaki disease (KD), most of them requiring admission to the pediatric intensive care unit (PICU). This study aimed to describe the prevalence and clinical characteristics of KD SARS-CoV-2 confirmed and negative patients during the pandemic in Spain. Material and Methods: Medical data of KD patients from January 1, 2018 until May 30, 2020 was collected from the KAWA-RACE study group. We compared the KD cases diagnosed during the COVID-19 period (March 1–May 30, 2020) that were either SARS-CoV-2 confirmed (CoV+) or negative (CoV–) to those from the same period during 2018 and 2019 (PreCoV). Results: One hundred and twenty-four cases were collected. There was a significant increase in cases and PICU admissions in 2020 (P-trend = 0.001 and 0.0004, respectively). CoV+ patients were significantly older (7.5 vs. 2.5 yr) and mainly non-Caucasian (64 vs. 29%), had incomplete KD presentation (73 vs. 32%), lower leucocyte (9.5 vs. 15.5 × 109) and platelet count (174 vs. 423 × 109/L), higher inflammatory markers (C-Reactive Protein 18.5vs. 10.9 mg/dl) and terminal segment of the natriuretic atrial peptide (4,766 vs. 505 pg/ml), less aneurysm development (3.8 vs. 11.1%), and more myocardial dysfunction (30.8 vs. 1.6%) than PreCoV patients. Respiratory symptoms were not increased during the COVID-19 period. Conclusion: The KD CoV+ patients mostly meet pediatric inflammatory multisystem syndrome temporally associated with COVID-19/multisystem inflammatory syndrome in children criteria. Whether this is a novel entity or the same disease on different ends of the spectrum is yet to be clarified.
登录
查看更多内容
影响因子：
1.4
作者：
Berenise Gamez-Gonzalez, Luisa;Moribe-Quintero, Isabel;Yamazaki-Nakashimada, Marco
通讯作者：
Yamazaki-Nakashimada, Marco
影响因子：
12.7
作者：
Shirato, Kazuya;Imada, Yoshio;Taguchi, Fumihiro
通讯作者：
Taguchi, Fumihiro
影响因子：
--
作者：
Kamvar, Zhian N;Cai, Jun;Jombart, Thibaut
通讯作者：
Jombart, Thibaut
影响因子：
8.1
作者：
Grimaud, Marion;Starck, Julie;Oualha, Mehdi
通讯作者：
Oualha, Mehdi
影响因子：
2.6
作者：
Buonsenso D;Riitano F;Valentini P
通讯作者：
Valentini P