The rise in cases of mucormycosis, candidiasis and aspergillosis amidst COVID19.
The rise in cases of mucormycosis, candidiasis and aspergillosis amidst COVID19.
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DOI：
10.1016/j.fbr.2021.09.003
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发表时间：
2021-12
影响因子：
6
通讯作者：
Patel P
中科院分区：
文献类型：
--
作者：
Ghosh A;Sarkar A;Paul P;Patel P
冠状病毒在全球范围内的爆发改变了医疗系统，也导致发展中国家和欠发达国家的医疗设施短缺。COVID 19疾病在自然界中是新的，具有高传染性和频繁的突变率，沿着，被称为在地球仪上是致命的。SARS-CoV-2感染的出现带来了无数的继发性并发症和合并症，导致新的治疗方法对卫生保健系统提出了额外的挑战。印度次大陆出现的变异和相关的基因突变使目前的局势更加恶化。适当的临床管理沿着流行病学研究以及科学研究和试验中的临床介绍是必要的，以对抗同时出现的菌株浪潮。本文总结了印度三种主要的真菌病暴发，即毛霉菌病、念珠菌病和曲霉病，并阐述了它们的亚型、发病机制、症状、治疗和检测技术。正在考虑的未来治疗方法的细节也详细阐述了沿着关于COVID 19如何与导致该国主要广泛真菌感染的免疫学进展相关的一般假设。有助于促进病毒增殖和侵袭性真菌感染的因素包括细胞介导的免疫、相关的免疫功能低下状况和减缓免疫机制的治疗方案。为了更好地理解真菌或细菌爆发，通过多中心国家和州研究小组进行审计非常重要，以识别模式并研究健康和共病COVID 19患者群体中真菌感染的当前病例。
The Coronavirus outbreak globally has changed the medical system and also led to a shortage of medical facilities in both developing and underdeveloped countries. The COVID19 disease, being novel in nature along with high infectivity and frequent mutational rate, has been termed to be fatal across the globe. The advent of infection by SARS-CoV-2 has brought a myriad of secondary complications and comorbidities resulting in additional challenges to the health care system induced by novel therapeutic procedures. The emerging variant with respect to the Indian subcontinent and the associated genetic mutations have worsened the situation at hand. Proper clinical management along with epidemiological studies and clinical presentations in scientific studies and trials is necessary in order to combat the simultaneous waves of emerging strains. This article summarizes three of the major fungal outbreaks in India namely mucormycosis, candidiasis and aspergillosis, and elaborates their subtypes, pathogenesis, symptoms and treatment and detection techniques. A detail of future therapeutics under consideration are also elaborated along with a general hypothesis on how COVID19 is related to immunological advances leading to major widespread fungal infection in the country. The factors that contribute in promoting virus proliferation and invasive fungal infections include cell-mediated immunity, associated immunocompromised conditions and treatment protocols that slows down immune mechanisms. To better comprehend a fungal or bacterial outbreak, it is very important to conduct audits mediated through multicenter national and state research teams for recognizing patterns and studying current cases of fungal infection in both healthy and comorbid groups of COVID19 patients.
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影响因子：
11.8
作者：
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DOI：
10.1016/j.bjid.2021.101597
发表时间：
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期刊：
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影响因子：
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影响因子：
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