Both food restriction and high-fat diet during gestation induce low birth weight and altered physical activity in adult rat offspring: the "Similarities in the Inequalities" model.
Both food restriction and high-fat diet during gestation induce low birth weight and altered physical activity in adult rat offspring: the "Similarities in the Inequalities" model.
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DOI：
10.1371/journal.pone.0118586
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发表时间：
2015
期刊：
影响因子：
3.7
通讯作者：
Silveira PP
中科院分区：
文献类型：
--
作者：
Cunha Fda S;Dalle Molle R;Portella AK;Benetti Cda S;Noschang C;Goldani MZ;Silveira PP
我们之前描述了一个人类的理论模型，称为“不平等中的相似性”，其中极端不平等的社会背景共存于一个复杂的场景中，促进成年后类似的健康结果。基于“不平等的相似性”现象的潜在适用性和进一步探索，本研究使用大鼠模型来研究妊娠期不同营养背景对后代成年后从事体力活动意愿的影响。将Sprague-Dawley大鼠定时交配，并随机分配至三个饮食组之一：对照组（随意），接受标准实验室食物自由采食; 50%限食组（FR），接受50%自由采食母鼠习惯性摄入量;或高脂饮食组（HF），接受含23%脂肪的饮食。从妊娠第10天至断奶提供饲料。在出生后24小时内，将幼仔与其他母鼠交叉寄养，形成以下组：Adlib_Adlib、FR_Adlib和HF_Adlib。评估母体食物消耗和体重增加，以及后代出生体重、生长、体力活动（在跑步轮中自由运动一周）、腹部肥胖和生化数据。进行Western印迹以评估背侧纹状体中的D2受体。在出生体重（出生时FR和HF组均小于Adlib组）和身体活动（FR_Adlib和HF_Adlib组均不同于Adlib_Adlib组，男性活动较少，女性活动较多）上观察到“不平等的相似性”效应。我们的研究结果有助于这样一种观点，即胎儿生命中的健康不平等可能会通过不同的生物学机制来规划后代成年生活中表现出的健康结果（例如改变的身体活动和代谢参数）。
We have previously described a theoretical model in humans, called “Similarities in the Inequalities”, in which extremely unequal social backgrounds coexist in a complex scenario promoting similar health outcomes in adulthood. Based on the potential applicability of and to further explore the “similarities in the inequalities” phenomenon, this study used a rat model to investigate the effect of different nutritional backgrounds during gestation on the willingness of offspring to engage in physical activity in adulthood. Sprague-Dawley rats were time mated and randomly allocated to one of three dietary groups: Control (Adlib), receiving standard laboratory chow ad libitum; 50% food restricted (FR), receiving 50% of the ad libitum-fed dam’s habitual intake; or high-fat diet (HF), receiving a diet containing 23% fat. The diets were provided from day 10 of pregnancy until weaning. Within 24 hours of birth, pups were cross-fostered to other dams, forming the following groups: Adlib_Adlib, FR_Adlib, and HF_Adlib. Maternal chow consumption and weight gain, and offspring birth weight, growth, physical activity (one week of free exercise in running wheels), abdominal adiposity and biochemical data were evaluated. Western blot was performed to assess D2 receptors in the dorsal striatum. The “similarities in the inequalities” effect was observed on birth weight (both FR and HF groups were smaller than the Adlib group at birth) and physical activity (both FR_Adlib and HF_Adlib groups were different from the Adlib_Adlib group, with less active males and more active females). Our findings contribute to the view that health inequalities in fetal life may program the health outcomes manifested in offspring adult life (such as altered physical activity and metabolic parameters), probably through different biological mechanisms.
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影响因子：
3
作者：
James MH;Campbell EJ;Walker FR;Smith DW;Richardson HN;Hodgson DM;Dayas CV
通讯作者：
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影响因子：
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DOI：
10.1016/0002-9378(89)90272-x
发表时间：
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DOI：
10.1097/hjr.0b013e32831f1b77
发表时间：
2009-04-01
影响因子：
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作者：
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通讯作者：
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影响因子：
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作者：
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