Adherence Measurements in HIV: New Advancements in Pharmacologic Methods and Real-Time Monitoring.
Adherence Measurements in HIV: New Advancements in Pharmacologic Methods and Real-Time Monitoring.
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DOI：
10.1007/s11904-018-0377-0
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发表时间：
2018-03
影响因子：
4.6
通讯作者：
Haberer JE
中科院分区：
文献类型：
--
作者：
Castillo-Mancilla JR;Haberer JE
在这篇综述中，我们介绍了抗逆转录病毒依从性的新进展，重点是药理学措施和实时依从性监测。此外，提出了如何将这些新措施纳入研究和临床护理的新策略。头发和干血斑中的抗逆转录病毒药物浓度是最近在艾滋病毒治疗和暴露前预防中评估的两种累积药物依从性和暴露的新药理学措施。使用电子设备进行的实时依从性监测也被证明具有高度的信息量、可行性和广泛接受性，当发现不依从性时提供了立即干预的可能性。这两种方法在预测疗效方面都比传统的依从性措施有相当大的优势。已经开发了新的方法来实时和长时间地客观监测依从性。需要进一步的研究来更好地了解这些措施如何优化依从性，并最终改善艾滋病毒治疗和预防的临床结果。
In this review we present new developments in antiretroviral adherence, focusing on pharmacological measures and real-time adherence monitoring. In addition, new strategies on how to incorporate these new measures into research and clinical care are proposed. Antiretroviral drug concentrations in hair and dried blood spots are two novel pharmacological measures of cumulative drug adherence and exposure that have been recently evaluated in HIV treatment and pre-exposure prophylaxis. Real-time adherence monitoring using electronic devices has also proven highly informative, feasible and well accepted, offering the possibility for an immediate intervention when non-adherence is detected. Both approaches offer considerable advantages over traditional adherence measures in predicting efficacy. New methods to objectively monitor adherence in real-time and over long time periods have been developed. Further research is required to better understand how these measures can optimize adherence and, ultimately, improve clinical outcomes in HIV treatment and prevention.
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影响因子：
2.5
作者：
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通讯作者：
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影响因子：
39.2
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作者：
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