Novel Magnetic Resonance Imaging-Based Method for Accurate Diagnosis of Meniere's Disease.
Novel Magnetic Resonance Imaging-Based Method for Accurate Diagnosis of Meniere's Disease.
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DOI：
10.3389/fsurg.2021.671624
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发表时间：
2021
影响因子：
1.8
通讯作者：
Naganawa S
中科院分区：
文献类型：
--
作者：
Ito T;Inoue T;Inui H;Miyasaka T;Yamanaka T;Kichikawa K;Takeda N;Kasahara M;Kitahara T;Naganawa S
背景：在病理学上，梅尼埃病的症状被认为与内淋巴积水有关。检查发现内淋巴积水可有助于梅尼埃病的准确诊断。我们以前报道了一种定量评价内淋巴积水的方法，即，通过使用内耳的三维磁共振成像（MRI）测量内淋巴空间的体积。本研究旨在证实我们的方法用于诊断梅尼埃病的有用性。在这里，我们提取了新的解释因素，诊断梅尼埃病，通过比较健康志愿者和梅尼埃病患者之间的内淋巴空间的体积。此外，我们验证了我们的方法，通过比较其诊断准确性与传统的方法。方法和发现：这是一项在我们大学医院（一家三级医院）的眩晕/头晕中心进行的前瞻性诊断准确性研究。86例确诊为单侧梅尼埃病的患者和47例健康志愿者（对照组和患者组分别为25例和33例男性，22例和53例女性）入选。所有参与者在静脉注射钆后4小时接受3特斯拉MRI以显示内淋巴间隙。测量内淋巴空间的体积，并构建梅尼埃病诊断模型，并与使用常规标准的模型进行比较，以确认所用方法的有效性。本研究提出的方法的受试者工作特征曲线下面积为0.924，显著高于使用常规标准得出的受试者工作特征曲线下面积（0.877）。在阈值处给出了四个指标，即灵敏度、特异性、阳性预测值和阴性预测值;与2D模型相比，3D模型的所有这些指标均获得了更高的分数。交叉验证的模型显示，改善是由于纳入半圆运河。结论：本方法对梅尼埃病的诊断具有较高的准确性。此外，我们还揭示了观察半规管对梅尼埃病诊断的重要性。所提出的方法可以有助于提供有效的症状缓解梅尼埃病。
Background: Pathologically, Meniere's disease symptoms are considered to be associated with endolymphatic hydrops. Examinations revealing endolymphatic hydrops can be useful for accurate Meniere's disease diagnosis. We previously reported a quantitative method for evaluating endolymphatic hydrops, i.e., by measuring the volume of the endolymphatic space using three-dimensional magnetic resonance imaging (MRI) of the inner ear. This study aimed to confirm the usefulness of our methods for diagnosing Meniere's disease. Here, we extracted new explanatory factors for diagnosing Meniere's disease by comparing the volume of the endolymphatic space between healthy volunteers and patients with Meniere's disease. Additionally, we validated our method by comparing its diagnostic accuracy with that of the conventional method. Methods and Findings: This is a prospective diagnostic accuracy study performed at vertigo/dizziness centre of our university hospital, a tertiary hospital. Eighty-six patients with definite unilateral Meniere's disease and 47 healthy volunteers (25 and 33 males, and 22 and 53 females in the control and patient groups, respectively) were enrolled. All participants underwent 3-Tesla MRI 4 h after intravenous injection of gadolinium to reveal the endolymphatic space. The volume of the endolymphatic space was measured and a model for Meniere's disease diagnosis was constructed and compared with models using conventional criteria to confirm the effectiveness of the methods used. The area under the receiver operating characteristic curve of the method proposed in this study was excellent (0.924), and significantly higher than that derived using the conventional criteria (0.877). The four indices, sensitivity, specificity, positive predictive value, and negative predictive value, were given at the threshold; all of these indices achieved higher scores for the 3D model compared to the 2D model. Cross-validation of the models revealed that the improvement was due to the incorporation of the semi-circular canals. Conclusions: Our method showed high diagnostic accuracy for Meniere's disease. Additionally, we revealed the importance of observing the semi-circular canals for Meniere's disease diagnosis. The proposed method can contribute toward providing effective symptomatic relief in Meniere's disease.
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影响因子：
3
作者：
Naganawa, Shinji;Yamazaki, Masahiro;Nakashima, Tsutomu
通讯作者：
Nakashima, Tsutomu
影响因子：
168.9
作者：
Sajjadi, Hamed;Paparella, Michael M.
通讯作者：
Paparella, Michael M.
影响因子：
1.4
作者：
Inui, Hiroshi;Sakamoto, Tsuyoshi;Kitahara, Tadashi
通讯作者：
Kitahara, Tadashi
影响因子：
5.9
作者：
Naganawa, S;Komada, T;Takizawa, O
通讯作者：
Takizawa, O
影响因子：
2.1
作者：
Guerkov, Robert;Flatz, Wilhelm;Krause, Eike
通讯作者：
Krause, Eike