The protection afforded to cattle immunized with Theileria annulata infected cell line is enhanced by subunit vaccine candidate TaSP.
The protection afforded to cattle immunized with Theileria annulata infected cell line is enhanced by subunit vaccine candidate TaSP.
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候选亚单位疫苗 TaSP 增强了对环形泰勒虫感染细胞系免疫的牛的保护作用
DOI：
10.1111/tbed.13374
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发表时间：
2020
影响因子：
4.3
通讯作者：
El Hussein A
中科院分区：
文献类型：
--
作者：
Saaid A;Salih D;Elhaj L;Abdalla M;Baumann M;Obara I;Ahmed J;Clausen PH;El Hussein A
热带泰勒虫病限制了苏丹乳制品业的发展，使用裂殖体减毒活疫苗进行疫苗接种被认为是一种有希望的控制措施。本研究旨在研究重组T的能力。 环状表面蛋白 (TaSP) 可提高减毒 Atbara 细胞系保护犊牛免受野外挑战的功效。为此，23 头杂交（弗里斯兰×凯纳纳）小牛被分为四组。第 1 组 (n = 5) 中的动物未接种疫苗。第 2 组 (n=6) 接受 Atbara 细胞系，第 3 组 (n=6) 动物在第 21、49 和 77 天接受三剂 TaSP 免疫，而第 4 组 (n=6) 动物在第 0 天接受细胞系疫苗，并在第 21、49 和 77 天接受三剂弗氏不完全佐剂 TaSP。最后一次 TaSP 后 28 天在已知热带泰勒虫病流行的地区，所有群体都面临着暴露于自然田间蜱虫感染的挑战。免疫后的免疫动物中未观察到热反应、梨质体或裂殖体。在攻击后，所有动物均表现出一系列严重程度不同的临床泰勒虫病症状。单独应用TaSP似乎没有保护作用。单独的细胞系的功效低于在接受组合细胞系疫苗和TaSP的组中观察到的100%的防止死亡的保护水平，表明该组合具有协同效应。
Tropical theileriosis constraints the development of the dairy industry in the Sudan and vaccination using live attenuated schizont vaccines is considered a promising measure for its control. The present study was carried out to investigate the ability of recombinantT. annulatasurface protein (TaSP) to improve the efficacy of the attenuated Atbara cell line in protecting calves against field challenge. To this end, 23 cross‐bred (Friesian × Kenana) calves were divided into four groups. Animals in group 1 (n= 5) were left unvaccinated. Group 2 (n= 6) received the Atbara cell line, animals in group 3 (n= 6) were immunized with three doses ofTaSP on days 21, 49 and 77, while animals in group 4 (n= 6) received the cell line vaccine on day 0 and three doses ofTaSP in Freund's incomplete adjuvant at days 21, 49 and 77. Twenty‐eight days after the lastTaSP boost, all groups were challenged by exposing them to natural field tick infestation in a region known to be endemic for tropical theileriosis. No thermal reactions, piroplasms or schizonts were observed in the immunized animals following immunization. Upon challenge, all animals showed a range of symptoms of clinical theileriosis with variable degrees of severity. The application ofTaSP alone appeared to have no effect in terms of protection. The efficacy of the cell line alone was lower than the 100% level of protection against mortality observed in the group that received the combined cell line vaccine andTaSP, suggesting a synergistic effect of this combination.
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影响因子：
2.2
作者：
Machugh ND;Burrells AC;Morrison WI
通讯作者：
Morrison WI
苏丹的 Hyalomma anatolicum anatolicum 蜱虫的自然感染率和传播。
影响因子：
2.7
作者：
D. Salih;O. E. Sharieff;A. G. Lazarus;S. Hassan;A. M. Hussein
通讯作者：
A. M. Hussein
DOI：
10.1007/978-94-009-8346-5_2
发表时间：
1981
期刊：
--
影响因子：
--
作者：
G. Uilenberg
通讯作者：
G. Uilenberg
使用不同的递送系统评价重组子孢子抗原SPAG-1作为针对环泰勒虫的候选疫苗
影响因子：
3.3
作者：
N. Boulter;D. Brown;G. Wilkie;S. Williamson;E. Kirvar;P. Knight;E. Glass;J. Campbell;S. Morzaria;V. Nene;A. Musoke;C. d'Oliveira;Marc;F. Jongejan;R. Hall
通讯作者：
R. Hall
苏丹阿纳托利希阿洛姆马与泰勒虫的自然感染率。
影响因子：
2.4
作者：
A. Walker;A. Latif;S. Morzaria;F. Jongejan
通讯作者：
F. Jongejan