Dissociable consequences of moderate and high volume stress are mediated by the differential energetic demands of stress.
Dissociable consequences of moderate and high volume stress are mediated by the differential energetic demands of stress.
复制标题
DOI：
10.1371/journal.pone.0273803
复制
发表时间：
2022
期刊：
影响因子：
3.7
通讯作者：
中科院分区：
文献类型：
--
作者：
暴露于创伤应激导致人类和非人类物种的持续、有害的行为和生物变化。然而，压力的影响并不总是一致的，因为暴露于不同的压力源往往会导致不同的影响。压力源的强度可能是决定压力后果的关键因素。虽然很难量化许多压力类型的强度，但电击暴露为我们提供了一种具有可量化参数的压力源（呈现长度x强度x数量=电击量）。因此，为了测试可能导致一些报告异质性的电击量的程序差异，我们使用了两种常见的电击程序。习得性无助是一种常见的行为结果，突出表现为随后的梭箱逃生缺陷，这需要大约100次无法控制的电击的相对高容量的压力（HVS）。相反，压力增强恐惧学习（SEFL）是另一种常见的行为结果，只需要15次电击的相对中等量的压力（MVS）。我们将大鼠暴露于HVS，MVS或无应激（NS），并检查对随后的恐惧学习和正常体重增加的影响。我们发现两个层次的压力的双重分离的影响。MVS增强了情境恐惧学习，但不影响体重，而HVS产生相反的模式。换句话说，更多的压力并不只是导致更大的损害。然后，我们测试的假设，不同的压力引起的后遗症引起的一个充满活力的挑战施加在海马HVS，而不是MVS。食用葡萄糖溶液的HVS大鼠确实表现出SEFL。此外，大鼠暴露于MVS和glucoprivated在单次试验的背景条件没有表现出SEFL。与HVS无法增强恐惧学习是因为对海马的影响这一假设相一致，HVS确实增强了独立于海马的听觉恐惧学习。最后，我们提供的证据表明，不同体积的压力产生分离的变化，谷氨酸受体蛋白在基底外侧杏仁核（BLA）和背海马（DH）。数据表明，虽然压力的强度是一个关键的决定因素，压力诱导的表型的影响是非线性的。
Exposure to traumatic stress leads to persistent, deleterious behavioral and biological changes in both human and non-human species. The effects of stress are not always consistent, however, as exposure to different stressors often leads to heterogeneous effects. The intensity of the stressor may be a key factor in determining the consequences of stress. While it is difficult to quantify intensity for many stress types, electric shock exposure provides us with a stressor that has quantifiable parameters (presentation length x intensity x number = shock volume). Therefore, to test the procedural differences in shock volume that may account for some reported heterogeneity, we used two common shock procedures. Learned helplessness is a commonly reported behavioral outcome, highlighted by a deficit in subsequent shuttle-box escape, which requires a relatively high-volume stress (HVS) of about 100 uncontrollable shocks. Conversely, stress-enhanced fear learning (SEFL) is another common behavioral outcome that requires a relatively moderate-volume stress (MVS) of only 15 shocks. We exposed rats to HVS, MVS, or no stress (NS) and examined the effects on subsequent fear learning and normal weight gain. We found doubly dissociable effects of the two levels of stress. MVS enhanced contextual fear learning but did not impact weight, while HVS produced the opposite pattern. In other words, more stress does not simply lead to greater impairment. We then tested the hypothesis that the different stress-induced sequalae arouse from an energetic challenge imposed on the hippocampus by HVS but not MVS. HVS rats that consumed a glucose solution did exhibit SEFL. Furthermore, rats exposed to MVS and glucoprivated during single-trial context conditioning did not exhibit SEFL. Consistent with the hypothesis that the inability of HVS to enhance fear learning is because of an impact on the hippocampus, HVS did enhance hippocampus-independent auditory fear learning. Finally, we provide evidence that stressors of different volumes produce dissociable changes in glutamate receptor proteins in the basolateral amygdala (BLA) and dorsal hippocampus (DH). The data indicate that while the intensity of stress is a critical determinant of stress-induced phenotypes that effect is nonlinear.
登录
查看更多内容
影响因子：
7.6
作者：
Anagnostaras, SG;Maren, S;Fanselow, MS
通讯作者：
Fanselow, MS
影响因子：
2.9
作者：
Bliss, TM;Sapolsky, RM
通讯作者：
Sapolsky, RM
影响因子：
10.6
作者：
Glenn, Daniel E.;Minor, Thomas R.;Craske, Michelle G.
通讯作者：
Craske, Michelle G.
DOI：
10.1037/0097-7403.19.2.121
发表时间：
1993-04-01
期刊：
JOURNAL OF EXPERIMENTAL PSYCHOLOGY-ANIMAL BEHAVIOR PROCESSES
影响因子：
--
作者：
FANSELOW, MS;DECOLA, JP;YOUNG, SL
通讯作者：
YOUNG, SL
影响因子：
3.5
作者：
FANSELOW, MS
通讯作者：
FANSELOW, MS