The time between paraquat ingestion and a negative dithionite urine test in an independent risk factor for death and organ failure in acute paraquat intoxication.
The time between paraquat ingestion and a negative dithionite urine test in an independent risk factor for death and organ failure in acute paraquat intoxication.
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DOI：
10.3346/jkms.2012.27.9.993
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发表时间：
2012-09
影响因子：
4.5
通讯作者：
Hong SY
中科院分区：
文献类型：
--
作者：
Seok S;Kim YH;Gil HW;Song HY;Hong SY
为了确定一种对摄入百草枯后时间变化不太敏感的预后标志物，我们评估了摄入百草枯和尿二硫脲测试阴性之间的时间，作为急性百草枯中毒患者的预后参数。本研究纳入了41例急性百草枯中毒患者，并对其进行了分析，以验证死亡率和器官功能障碍的重要决定因素。摄入百草枯量、血浆百草枯水平和尿二硫脲试验阴性时间是预测死亡率的重要独立危险因素。摄入百草枯的量和尿二硫脲试验阴性的时间是预测器官功能障碍的独立危险因素。尿二硫脲试验阴性转化时间的临界值为34.5小时，对死亡率的敏感性和特异性分别为71.4%和75.0%。34.5 hr以上急性肾损伤和呼吸衰竭的发生率分别为100%和85.0%。总之，尿二硫脲试验阴性的时间是预测急性百草枯中毒患者死亡率和/或基本器官衰竭的可靠指标，存活72小时。
To identify a prognostic marker that is less sensitive to variations in the elapsed time since paraquat ingestion, we assessed the time between paraquat ingestion and a negative dithionite urine test as a prognostic parameter in patients with acute paraquat intoxication. Forty-one patients with acute paraquat intoxication were enrolled in this study and analyzed to verify significant determinants of mortality and organ dysfunction. The amount of paraquat ingested, paraquat plasma levels, and the time to a negative urine dithionite test were significant independent risk factors predicting mortality. The amount of paraquat ingestion, and the time to a negative urine dithionite test were independent risk factors predicting organ dysfunction. With a cut-off value of 34.5 hr for the time to negative conversion of the urine dithionite test, the sensitivity and specificity for mortality were 71.4% and 75.0%, respectively. The incidence of acute kidney injury and respiratory failure above 34.5 hr were 100% and 85.0%, respectively. In conclusion, the time to a negative urine dithionite test is the reliable marker for predicting mortality and/or essential organ failure in patients with acute paraquat intoxication, who survive 72 hr.
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影响因子：
4.5
作者：
Kang, Moon-Soo;Gil, Hyo-Wook;Yang, Jong-Oh;Lee, Eun-Young;Hong, Sae-Yong
通讯作者：
Hong, Sae-Yong
影响因子：
3.3
作者：
Gil, Hyo-Wook;Kang, Mun-Soo;Hong, Sae-Yong
通讯作者：
Hong, Sae-Yong
影响因子：
2.2
作者：
IKEBUCHI, J;PROUDFOOT, AT;OKADA, K
通讯作者：
OKADA, K
影响因子：
3.2
作者：
de Almeida, Rafael Menck;Yonamine, Mauricio
通讯作者：
Yonamine, Mauricio
DOI：
10.1016/s0021-9673(00)96258-7
发表时间：
1984-01-01
期刊：
JOURNAL OF CHROMATOGRAPHY
影响因子：
--
作者：
KAWASE, S;KANNO, S;UKAI, S
通讯作者：
UKAI, S