Sex Differences in Dopamine Receptors and Relevance to Neuropsychiatric Disorders.
Sex Differences in Dopamine Receptors and Relevance to Neuropsychiatric Disorders.
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DOI：
10.3390/brainsci11091199
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发表时间：
2021-09-11
期刊：
影响因子：
3.3
通讯作者：
Perreault ML
中科院分区：
文献类型：
--
作者：
Williams OOF;Coppolino M;George SR;Perreault ML
多巴胺是一种重要的神经递质，在神经精神疾病中起着关键作用。几十年来，多巴胺能信号的性别差异已经被公认，并与多巴胺相关行为和各种神经精神障碍的性别特异性异质性有关。然而，无论是在健康还是在这些疾病中，评估多巴胺信号的性别差异的研究总数都很低。这篇综述将总结关于先天多巴胺受体表达和功能的性别差异的已知结果，以及已知的多巴胺在成瘾、抑郁、焦虑、精神分裂症和注意缺陷多动障碍中的性别特异性作用。由于男性和女性受试者在涉及多巴胺信号的疾病或利用针对多巴胺受体的药物干预的反应方面的预后、诊断和症状学上的差异，了解多巴胺受体的根本性别差异对于个体化治疗策略至关重要。
Dopamine is an important neurotransmitter that plays a key role in neuropsychiatric illness. Sex differences in dopaminergic signaling have been acknowledged for decades and have been linked to sex-specific heterogeneity in both dopamine-related behaviours as well as in various neuropsychiatric disorders. However, the overall number of studies that have evaluated sex differences in dopamine signaling, both in health and in these disorders, is low. This review will bring together what is known regarding sex differences in innate dopamine receptor expression and function, as well as highlight the known sex-specific roles of dopamine in addiction, depression, anxiety, schizophrenia, and attention deficit hyperactivity disorder. Due to differences in prognosis, diagnosis, and symptomatology between male and female subjects in disorders that involve dopamine signaling, or in responses that utilize pharmacological interventions that target dopamine receptors, understanding the fundamental sex differences in dopamine receptors is of vital importance for the personalization of therapeutic treatment strategies.
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