RegulonDB (version 6.0): gene regulation model of Escherichia coli K-12 beyond transcription, active (experimental) annotated promoters and Textpresso navigation.
RegulonDB (version 6.0): gene regulation model of Escherichia coli K-12 beyond transcription, active (experimental) annotated promoters and Textpresso navigation.
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DOI：
10.1093/nar/gkm994
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发表时间：
2008-01
影响因子：
14.9
通讯作者：
Collado-Vides J
中科院分区：
文献类型：
--
作者：
Gama-Castro S;Jiménez-Jacinto V;Peralta-Gil M;Santos-Zavaleta A;Peñaloza-Spinola MI;Contreras-Moreira B;Segura-Salazar J;Muñiz-Rascado L;Martínez-Flores I;Salgado H;Bonavides-Martínez C;Abreu-Goodger C;Rodríguez-Penagos C;Miranda-Ríos J;Morett E;Merino E;Huerta AM;Treviño-Quintanilla L;Collado-Vides J
RegulondB（http://regulondb.ccg.unam.mx/）是主要参考数据库，该数据库提供了Escherichia Coli K12的转录调节网络的精选知识，目前是目前最著名的电子编码数据库，该数据库是任何自由 - 任何自由的调节网络Living有机体总结了6.0版的改进，新的生物学和新功能由它们的相应证据支持，现在被分类为强或弱的因素。相应的-10和-35盒子除了策划的文献外，我们还添加了大约300个实验映射的启动子努力。现在可以使用TextPresso文本挖掘引擎搜索4000多个策划笔记。
RegulonDB (http://regulondb.ccg.unam.mx/) is the primary reference database offering curated knowledge of the transcriptional regulatory network of Escherichia coli K12, currently the best-known electronically encoded database of the genetic regulatory network of any free-living organism. This paper summarizes the improvements, new biology and new features available in version 6.0. Curation of original literature is, from now on, up to date for every new release. All the objects are supported by their corresponding evidences, now classified as strong or weak. Transcription factors are classified by origin of their effectors and by gene ontology class. We have now computational predictions for σ54 and five different promoter types of the σ70 family, as well as their corresponding −10 and −35 boxes. In addition to those curated from the literature, we added about 300 experimentally mapped promoters coming from our own high-throughput mapping efforts. RegulonDB v.6.0 now expands beyond transcription initiation, including RNA regulatory elements, specifically riboswitches, attenuators and small RNAs, with their known associated targets. The data can be accessed through overviews of correlations about gene regulation. RegulonDB associated original literature, together with more than 4000 curation notes, can now be searched with the Textpresso text mining engine.
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影响因子：
14.9
作者：
Kersey, P;Bower, L;Apweiler, R
通讯作者：
Apweiler, R
影响因子：
11.4
作者：
Merino, E;Yanofsky, C
通讯作者：
Yanofsky, C
影响因子：
5.8
作者：
Ciria, R;Abreu-Goodger, C;Merino, E
通讯作者：
Merino, E
影响因子：
3
作者：
Rodriguez-Penagos, Carlos;Salgado, Heladia;Collado-Vides, Julio
通讯作者：
Collado-Vides, Julio
影响因子：
14.9
作者：
Griffiths-Jones S;Moxon S;Marshall M;Khanna A;Eddy SR;Bateman A
通讯作者：
Bateman A