The porcine innate immune system: an update.
The porcine innate immune system: an update.
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DOI：
10.1016/j.dci.2014.03.022
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发表时间：
2014-08
影响因子：
2.9
通讯作者：
Meurens F
中科院分区：
文献类型：
--
作者：
Mair KH;Sedlak C;Käser T;Pasternak A;Levast B;Gerner W;Saalmüller A;Summerfield A;Gerdts V;Wilson HL;Meurens F
本文综述了猪先天免疫系统的最新研究进展。猪的先天免疫系统与人、鼠的先天免疫系统进行了比较。强调了猪作为人类疾病模型的重要性。在过去的几年里，我们看到在生物医学研究中对猪的兴趣和需求越来越大。家猪在解剖学、遗传学和生理学方面与人类密切相关，通常是临床前阶段评估新疫苗和治疗方法的首选模型。然而，猪作为模型可以提供更多的东西，可以作为许多生物医学应用的模型，包括衰老研究、医学成像和药物研究等。在这篇综述中，我们将概述猪的先天免疫系统，描述其解剖学和生理学的关键特征，并讨论参与其中的关键因素。特别是，我们比较了猪的先天免疫系统与人类的先天免疫系统，并强调了猪作为人类疾病模型的重要性。
This review provides an updated overview of porcine innate immune system. Porcine innate immune system is compared that of human and mouse. The importance of the pig as model for human disease is underlined. Over the last few years, we have seen an increasing interest and demand for pigs in biomedical research. Domestic pigs (Sus scrofa domesticus) are closely related to humans in terms of their anatomy, genetics, and physiology, and often are the model of choice for the assessment of novel vaccines and therapeutics in a preclinical stage. However, the pig as a model has much more to offer, and can serve as a model for many biomedical applications including aging research, medical imaging, and pharmaceutical studies to name a few. In this review, we will provide an overview of the innate immune system in pigs, describe its anatomical and physiological key features, and discuss the key players involved. In particular, we compare the porcine innate immune system to that of humans, and emphasize on the importance of the pig as model for human disease.
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影响因子：
8
作者：
Adam, S. J.;Rund, L. A.;Counter, C. M.
通讯作者：
Counter, C. M.
影响因子：
6.4
作者：
Agah, A;Montalto, MC;Stahl, GL
通讯作者：
Stahl, GL
影响因子：
1
作者：
Baarsch, MJ;Foss, DL;Murtaugh, MP
通讯作者：
Murtaugh, MP
影响因子：
4.2
作者：
Boudry, Gaelle;Douard, Veronique;Le Huerou-Luron, Isabelle
通讯作者：
Le Huerou-Luron, Isabelle
影响因子：
5.1
作者：
Alves, M. P.;Neuhaus, V.;Summerfield, A.
通讯作者：
Summerfield, A.