FEEDING-INDUCED RAPID RESETTING OF THE HEPATIC CIRCADIAN CLOCK IS ASSOCIATED WITH ACUTE INDUCTION OF PER2 AND DEC1 TRANSCRIPTION IN RATS
FEEDING-INDUCED RAPID RESETTING OF THE HEPATIC CIRCADIAN CLOCK IS ASSOCIATED WITH ACUTE INDUCTION OF PER2 AND DEC1 TRANSCRIPTION IN RATS
复制标题
进食引起的肝脏生物钟快速重置与大鼠 PER2 和 DEC1 转录的急性诱导有关
DOI：
10.3109/07420520903398625
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发表时间：
2010-02
影响因子：
2.8
通讯作者：
Fu, Zhengwei
中科院分区：
文献类型：
--
作者：
Wu, Tao;Ni, Yinhua;Kato, Hisanori;Fu, Zhengwei
主时钟与光信号的同步与 Per1 的快速诱导有关，Per1 在启动光诱导的昼夜节律重置中发挥着重要作用。然而，食物夹带外周时钟中时钟基因表达的转录机制尚未得到充分评估。为了了解食物线索如何影响哺乳动物的外周时钟，我们检查了大鼠肝脏中时钟基因表达对不同进食刺激的反应。食物诱导的肝脏时钟比光诱导的 SCN 时钟更灵活，可以在一天中的任何时间快速重置。 30 分钟的喂养刺激足以在 1 小时内显着诱导 Per2 和 Dec1 的表达，并以较长的时间间隔改变肝脏时钟中其他选定时钟基因（Bmal1、Cry1、Per1、Per3、Dec2 和 Rev-erba）的转录水平和昼夜节律阶段。此外，在所检查的时钟基因中，Per2对食物线索最敏感，最少量的食物就可以显着诱导这种信号。此外，与其他肝时钟基因相比，无论光/暗周期如何变化，Per2的进食逆转诱导的12小时相移都可以快速且一致地完成。总之，进食引起的肝脏生物钟重置与 Per2 和 Dec1 转录的急性诱导有关，它们可能作为启动这种进食引起的昼夜节律重置的主要和次要输入调节因子。 （作者通讯：azwfu2003@yahoo.com.cn）
The synchronization of the master clock to photic cues is associated with a rapid induction of Per1, which plays an important role in initiating light-induced circadian resetting. However, the transcriptional mechanisms of clock gene expression in food-entrainable peripheral clocks have not been fully assessed. To understand how food cues might entrain a mammalian peripheral clock, we examined the responses in the expression of clock genes in rat livers to different feeding stimuli. The food-entrainable liver clock is more flexible than the light-entrainable SCN clock and can be reset rapidly at any time of day. A 30 min feeding stimulus was sufficient to significantly induce the expression of Per2 and Dec1 within 1 h and alter the transcript levels and circadian phases of other selected clock genes (Bmal1, Cry1, Per1, Per3, Dec2, and Rev-erba) in the liver clock at longer time intervals. Moreover, among the examined clock genes, Per2 was most sensitive to food cues, which could be significantly induced by a minimal amount of food. Furthermore, in contrast to the other hepatic clock genes, the feeding reversal-induced 12 h phase shift of Per2 could be rapidly and consistently accomplished, regardless of the shift of the light/dark cycle. In conclusion, the feeding-induced resetting of the circadian clock in the liver is associated with the acute induction of Per2 and Dec1 transcription, which may serve as the main and secondary input regulators that initiate this feeding-induced circadian resetting. (Author correspondence: azwfu2003@yahoo.com.cn)
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影响因子：
16.2
作者：
Shearman, LP;Zylka, MJ;Reppert, SM
通讯作者：
Reppert, SM
影响因子：
3.5
作者：
Wu, Tao;Jin, Yuanxiang;Fu, Zhengwei
通讯作者：
Fu, Zhengwei
影响因子：
2.8
作者：
Portaluppi, Francesco;Touitou, Yvan;Smolensky, Michael H.
通讯作者：
Smolensky, Michael H.
DOI：
10.1152/ajpregu.1998.274.6.r1751
发表时间：
1998-06-01
影响因子：
2.8
作者：
Challet, E;Solberg, LC;Turek, FW
通讯作者：
Turek, FW
影响因子：
1.1
作者：
Yue Dong;Tao Wu;Y. Ni;H. Kato;Z. Fu
通讯作者：
Yue Dong;Tao Wu;Y. Ni;H. Kato;Z. Fu