Exosomes in the f ield of reproduction: A scientometric study and visualization analysis.

Exosomes in the f ield of reproduction: A scientometric study and visualization analysis.
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DOI:
10.3389/fphar.2022.1001652
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发表时间:
2022
影响因子:
5.6
通讯作者:
--
中科院分区:
医学2区
文献类型:
--
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背景:外切体在生殖生物医学领域的诊断能力备受关注。这项科学计量学研究的目的是用可视化的方法对生殖领域内有关外切体的论文的知识结构、热点问题和研究趋势进行统计和定性的评估。方法:检索Web of Science核心文库,检索外显子在生殖领域的研究。我们使用VOS查看器、CiteSpace和Microsoft Excel进行了文献计量和视觉分析。结果:经数据库检索,共纳入文献1011篇,每年发表的文献数量持续增加。这些出版物来自61个国家或地区,其中美国的数量最多。昆士兰大学是进行这项研究的主要机构。《胎盘》杂志包含的研究数量最多。共有5,247名作者。卡洛斯·所罗门被联合引用的论文数量最多。Exosome、细胞外小泡、妊娠、microRNAs、先兆子痫、胎盘、微泡、基因表达、生物标志物和早期妊娠是最常用的术语。结论:生殖生物医学中的外切体研究正在蓬勃发展。未来的研究可能会集中在外切体作为配子形成和受精、怀孕和与生殖相关的癌症的生物标记物上。除了注重基础研究外,还应注重研究成果的应用和不孕症患者外显子的研究。
Background: The diagnostic capabilities of exosomes in the field of reproductive biomedicine have attracted much attention. The aim of this scientometric study was to statistically and qualitatively assess the knowledge structure, hot issues, and research trends of papers about exosomes in the field of reproduction using visualization methods. Methods: The Web of Science Core Collection was searched for studies on exosomes in the field of reproduction. We performed bibliometric and visual analyses using VOSviewer, CiteSpace, and Microsoft Excel. Results: After database search, 1,011 articles were included, with number of studies being published every year continually increasing. These publications came from 61 nations or regions, with the US having the highest number. The University of Queensland was the main institution in which the research was conducted. The journal Placenta contained the highest number studies. There were 5,247 authors in total. Carlos Salomon had the highest number of papers with co-citations. Exosomes, extracellular vesicles, pregnancy, microRNAs, preeclampsia, placenta, microvesicles, gene expression, biomarkers, and first trimester were the most frequently used terms. Conclusion: Exosome research is booming in reproductive biomedicine. Future studies will likely focus on exosomes as biomarkers in gamete formation and fertilization, pregnancy, and cancers associated with reproduction. In addition to focusing on fundamental research, we should concentrate on the application of the results and the investigation of exosomes in infertile patients.
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