Parental nutrient intake and risk of retinoblastoma resulting from new germline RB1 mutation.
Parental nutrient intake and risk of retinoblastoma resulting from new germline RB1 mutation.
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父母的营养摄入量和因新种系RB1突变引起的视网膜细胞瘤的风险。
DOI：
10.1007/s10552-012-0120-x
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发表时间：
2013-02
影响因子：
2.3
通讯作者：
Tseng, Marilyn
中科院分区：
文献类型：
--
作者：
Bunin, Greta R.;Li, Yimei;Ganguly, Arupa;Meadows, Anna T.;Tseng, Marilyn
我们进行了一项病例对照研究，以检查父母在孩子受孕前的营养摄入在孩子患散发性双侧视网膜母细胞瘤风险中的作用，这种风险是由一种新的生殖系RB1突变引起的。来自9个北美机构和269个朋友和亲戚对照组的206个病例的父母参加了研究; 182个病例和223个对照组的父亲和202个病例和260个对照组的母亲在孩子受孕前一年的电话采访中提供了关于他们饮食的有用信息。我们还询问了父母关于补充剂的情况，补充剂是使用者的重要营养来源。父亲摄入乳制品相关营养素和使用钙补充剂与风险降低相关，而他摄入铜，锰和维生素E与风险增加相关。母亲在怀孕前使用多种维生素与较低的风险有关，因为她摄入了这些补充剂中的几种微量营养素。在从多个相关因素中阐明主要因素的分析中，最可靠的结果是父亲的钙摄入量（700 mg增加调整OR = 0.46 - 0.63）和钙补充剂的使用（OR = 0.35 - 0.41）以及母亲的多种维生素使用（OR = 0.28 - 0.48）。很少有直接相关的研究，但一些数据间接支持与父亲的钙摄入量和母亲的使用多种维生素的负相关的生物可接受性;然而，我们不能排除偏见，混杂或机会的贡献。我们的发现为进一步研究饮食在视网膜母细胞瘤病因学和新的生殖系突变中的作用提供了一个起点。
We conducted a case-control study to examine the role of parents’ nutrient intake before their child’s conception in the child’s risk of sporadic bilateral retinoblastoma, which results from a new germline RB1 mutation. Parents of 206 cases from 9 North American institutions and 269 friend and relative controls participated; fathers of 182 cases and 223 controls and mothers of 202 cases and 260 controls provided useable information in telephone interviews on their diet in the year before the child’s conception. We also asked parents about supplements, a significant source of nutrients in users. Father’s intake of dairy-associated nutrients and his use of calcium supplements were associated with decreased risk while his intake of copper, manganese, and vitamin E was associated with increased risk. Mother’s use of multivitamins close to conception was associated with lower risk as was her intake of several micronutrients found in these supplements. In analyses to elucidate the primary factor from multiple correlated factors, the most robust findings were for father’s calcium intake (adjusted OR=0.46 – 0.63 for 700 mg increase) and calcium supplement use (OR=0.35 – 0.41) and mother’s multivitamin use (ORs 0.28 – 0.48). There are few directly relevant studies but some data indirectly support the biologic plausibility of the inverse associations with father’s calcium intake and mother’s use of multivitamins; however, we cannot rule out contributions of bias, confounding, or chance. Our findings provide a starting point for further investigation of diet in the etiology of retinoblastoma and new germline mutation generally.
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影响因子：
9.8
作者：
Richter, S;Vandezande, K;Gallie, B
通讯作者：
Gallie, B
影响因子：
3.3
作者：
XU, B;CHIA, SE;ONG, CN
通讯作者：
ONG, CN
影响因子：
2.8
作者：
Bunin, Greta R.;Tseng, Marilyn;Ganguly, Arupa
通讯作者：
Ganguly, Arupa
影响因子：
2.8
作者：
Bunin, Greta R.;Vardhanabhuti, Saran;Mitra, Nandita
通讯作者：
Mitra, Nandita
影响因子：
5
作者：
WILLETT, WC;SAMPSON, L;SPEIZER, FE
通讯作者：
SPEIZER, FE