Nicotinic acetylcholine signaling is required for motor learning but not for rehabilitation from spinal cord injury.
Nicotinic acetylcholine signaling is required for motor learning but not for rehabilitation from spinal cord injury.
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DOI：
10.4103/1673-5374.346544
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发表时间：
2023-03
影响因子：
6.1
通讯作者：
Hollis, Edmund R., II
中科院分区：
文献类型：
--
作者：
Li, Yue;Hollis, Edmund R., II
关键词：
脊髓损伤的治疗干预是有限的，许多方法依赖于通过康复训练加强剩余的基质和推动恢复。与学习新的补偿策略相比，康复侧重于恢复因受伤而失去的运动。脊髓损伤后先前学习的运动的康复是否需要运动学习的分子机制，或者它是否参与先前训练的运动回路而不需要新的学习仍然是一个悬而未决的问题。在这项研究中，小鼠被随机分配在运动学习试验之前接受腹膜内注射泛烟碱非竞争性拮抗剂美加明和烟碱α7亚基选择性拮抗剂甲基乌头碱柠檬酸盐或溶剂（生理盐水），然后在运动学习之后随机重新分配用于损伤后康复研究。采用颈脊髓背柱损伤作为不完全损伤模型。本研究的结果表明，烟碱乙酰胆碱信号是需要的运动学习的单颗粒达到任务，但它是不必要的相同的任务损伤后的康复。我们的研究结果表明，支持补偿性运动学习策略的分子机制和恢复脊髓损伤造成的行为损失之间存在着重要的差异。
Therapeutic intervention for spinal cord injury is limited, with many approaches relying on strengthening the remaining substrate and driving recovery through rehabilitative training. As compared with learning novel compensatory strategies, rehabilitation focuses on restoring movements lost to injury. Whether rehabilitation of previously learned movements after spinal cord injury requires the molecular mechanisms of motor learning, or if it engages previously trained motor circuits without requiring novel learning remains an open question. In this study, mice were randomly assigned to receive intraperitoneal injection with the pan-nicotinic, non-competitive antagonist mecamylamine and the nicotinic α7 subunit selective antagonist methyllycaconitine citrate salt or vehicle (normal saline) prior to motor learning assays, then randomly reassigned after motor learning for rehabilitation study post-injury. Cervical spinal cord dorsal column lesion was used as a model of incomplete injury. Results of this study showed that nicotinic acetylcholine signaling was required for motor learning of the single pellet-reaching task but it was dispensable for the rehabilitation of the same task after injury. Our findings indicate that critical differences exist between the molecular mechanisms supporting compensatory motor learning strategies and the restoration of behavior lost to spinal cord injury.
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影响因子：
16.2
作者：
Conner, JM;Chiba, AA;Tuszynski, MH
通讯作者：
Tuszynski, MH
影响因子：
5.3
作者：
Li, Yue;Hollis, Edmund
通讯作者：
Hollis, Edmund
影响因子：
--
作者：
Boskovic, Zoran;Meier, Sonja;Coulson, Elizabeth J
通讯作者：
Coulson, Elizabeth J
影响因子：
25
作者：
Hollis ER 2nd;Ishiko N;Yu T;Lu CC;Haimovich A;Tolentino K;Richman A;Tury A;Wang SH;Pessian M;Jo E;Kolodkin A;Zou Y
通讯作者：
Zou Y
影响因子：
3.4
作者：
CASTROALAMANCOS, MA;GARCIASEGURA, LM;BORRELL, J
通讯作者：
BORRELL, J