Sense and antisense transcripts of convergent gene pairs in Arabidopsis thaliana can share a common polyadenylation region.
Sense and antisense transcripts of convergent gene pairs in Arabidopsis thaliana can share a common polyadenylation region.
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DOI：
10.1371/journal.pone.0016769
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发表时间：
2011-02-02
期刊：
影响因子：
3.7
通讯作者：
Meyer P
中科院分区：
文献类型：
--
作者：
Zubko E;Kunova A;Meyer P
拟南芥基因组中含有大量编码正义和反义转录本的基因对，这些基因对的3′端区域重叠，表明天然反义转录在调节正义基因表达或转录本加工中的潜在作用。当我们绘制了三个植物基因对的poly（A）转录本与长重叠的反义转录本时，我们确定了三个基因对中的两个的不寻常的转录本组成。两个基因对编码一类长义转录本和一类短义转录本，其终止于与由相反链编码的反义转录本相同的多聚腺苷酸化区域内。我们发现，存在的短正义转录本是不依赖于表达的反义转录本。这反驳了正义和反义poly（A）转录物的共同终止区是反义特异性调节的结果的假设。我们推测，对于某些基因的进化可能有特别有利的替代聚腺苷酸化事件，缩短转录长度的基因对重叠的正义/反义转录，如果这降低了dsRNA形成和转录降解的可能性。
The Arabidopsis genome contains a large number of gene pairs that encode sense and antisense transcripts with overlapping 3′ regions, indicative for a potential role of natural antisense transcription in regulating sense gene expression or transcript processing. When we mapped poly(A) transcripts of three plant gene pairs with long overlapping antisense transcripts, we identified an unusual transcript composition for two of the three gene pairs. Both genes pairs encoded a class of long sense transcripts and a class of short sense transcripts that terminate within the same polyadenylation region as the antisense transcripts encoded by the opposite strand. We find that the presence of the short sense transcript was not dependent on the expression of an antisense transcript. This argues against the assumption that the common termination region for sense and antisense poly(A) transcripts is the result of antisense-specific regulation. We speculate that for some genes evolution may have especially favoured alternative polyadenylation events that shorten transcript length for gene pairs with overlapping sense/antisense transcription, if this reduces the likelihood for dsRNA formation and transcript degradation.
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