Parental ages and levels of DNA methylation in the newborn are correlated.
Parental ages and levels of DNA methylation in the newborn are correlated.
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DOI：
10.1186/1471-2350-12-47
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发表时间：
2011-03-31
影响因子：
--
通讯作者：
Krushkal J
中科院分区：
文献类型：
--
作者：
Adkins RM;Thomas F;Tylavsky FA;Krushkal J
随着年龄的增长，DNA甲基化模式的变化经常被观察到，并与正常的衰老过程及其相关的疾病，特别是癌症风险的增加有关。此外，年长父母的子女患癌症、糖尿病和神经发育障碍的风险显著增加。在年长父母的子女中，只有一部分风险增加可以归因于不分离和染色体重排。利用对168名新生儿队列中27,578个CpG二核苷酸的全基因组调查，我们研究了新生儿DNA甲基化与父母和新生儿的各种特征之间的关系。我们发现142个基因的144个CPGS的甲基化水平与母亲的年龄显著相关。与父亲年龄的相关性较弱。在这些基因中，与癌症相关的过程被过度表达，与神经调节、葡萄糖/碳水化合物代谢、核质运输和转录调节相关的功能也是如此。在甲基化方面表现出性别差异的CPG绝大多数位于X染色体上，尽管在以前被证明在甲基化水平上表现出性别差异的基因中发现了一小部分常染色体CPG。这些结果表明，出生时CpG甲基化水平存在差异，这与父母的年龄有关，并可能影响儿童时期和一生的疾病风险。
Changes in DNA methylation patterns with age frequently have been observed and implicated in the normal aging process and its associated increasing risk of disease, particularly cancer. Additionally, the offspring of older parents are at significantly increased risk of cancer, diabetes, and neurodevelopmental disorders. Only a proportion of these increased risks among the children of older parents can be attributed to nondisjunction and chromosomal rearrangements. Using a genome-wide survey of 27,578 CpG dinucleotides in a cohort of 168 newborns, we examined the relationship between DNA methylation in newborns and a variety of parental and newborn traits. We found that methylation levels of 144 CpGs belonging to 142 genes were significantly correlated with maternal age. A weaker correlation was observed with paternal age. Among these genes, processes related to cancer were over-represented, as were functions related to neurological regulation, glucose/carbohydrate metabolism, nucleocytoplasmic transport, and transcriptional regulation. CpGs exhibiting gender differences in methylation were overwhelmingly located on the X chromosome, although a small subset of autosomal CpGs were found in genes previously shown to exhibit gender-specific differences in methylation levels. These results indicate that there are differences in CpG methylation levels at birth that are related to parental age and that could influence disease risk in childhood and throughout life.
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影响因子：
3.7
作者：
Boks MP;Derks EM;Weisenberger DJ;Strengman E;Janson E;Sommer IE;Kahn RS;Ophoff RA
通讯作者：
Ophoff RA
影响因子：
4.5
作者：
Christensen BC;Houseman EA;Marsit CJ;Zheng S;Wrensch MR;Wiemels JL;Nelson HH;Karagas MR;Padbury JF;Bueno R;Sugarbaker DJ;Yeh RF;Wiencke JK;Kelsey KT
通讯作者：
Kelsey KT
影响因子：
3.7
作者：
Liu J;Morgan M;Hutchison K;Calhoun VD
通讯作者：
Calhoun VD
影响因子：
5
作者：
Lu, Yani;Ma, Huiyan;Wang, Sophia S.
通讯作者：
Wang, Sophia S.
影响因子：
3.5
作者：
Cardwell, CR;Carson, DJ;Patterson, CC
通讯作者：
Patterson, CC