Analysis of B7-H4 expression in metastatic pleural adenocarcinoma and therapeutic potential of its antagonists.
Analysis of B7-H4 expression in metastatic pleural adenocarcinoma and therapeutic potential of its antagonists.
复制标题
B7-H4在转移性胸膜腺癌中的表达及其拮抗剂的治疗潜力分析
DOI：
10.1186/s12885-017-3615-8
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发表时间：
2017-09-18
期刊：
影响因子：
3.8
通讯作者：
Huang JA
中科院分区：
文献类型：
--
作者：
Chen C;Qu QX;Xie F;Zhu WD;Zhu YH;Huang JA
恶性胸腔积液（MPE）的发病率不断上升，预后不良，需要寻找有效的治疗方法。抑制性B7-H4在许多不同的人类癌症中表达，但其在恶性胸膜组织中的作用尚未确定。方法对转移性胸膜腺癌（MPA）和早期肺腺癌患者进行临床和统计学分析。采用免疫组织化学和共聚焦显微镜检测B7-H4在肿瘤细胞中的表达。通过使用MPE模型，我们寻求抗b7 - h4单抗对MPE的潜在免疫治疗。结果与早期肺腺癌相比，MPA核膜B7-H4表达水平较高，胞质B7-H4表达水平较低。核膜B7-H4表达与Ki-67表达呈正相关，提示MPA预后可能较差。在小鼠MPE模型中，胸膜内注射抗b7 - h4单抗可有效抑制MPE的形成。结论B7-H4在MPA中的表达具有重要意义，值得进一步探索MPE的潜在免疫治疗方法。
BackgroundThe increasing incidence and poor outcome associated with malignant pleural effusion (MPE) requires finding an effective treatment for this disease. Inhibitory B7-H4 is expressed in many different human cancers but its role in malignant pleural tissue has yet to be established.MethodsHere, patients with metastatic pleural adenocarcinoma (MPA) or with early-stage lung adenocarcinoma were clinically and statistically analyzed. Immunohistochemistry and confocal microscopy were used to determinate the expression of B7-H4 in the cancer cells. By using MPE model, we sought to a potential immunotherapy for MPE with anti-B7-H4 mAb.ResultsWhen compared to early-stage lung adenocarcinoma, MPA possessed higher level of nuclei membranous B7-H4 and lower cytoplasmic B7-H4 expression. Also, nuclei membranous B7-H4 expression was found to be positively correlated to Ki-67 expression, and indicated a possible poor prognosis of MPA. In mouse MPE model, intra-pleurally injection of anti-B7-H4 mAb effectively suppressed MPE formation.ConclusionsTaken together, our data was in support of the significance of B7-H4 expression in MPA, which also suggest it warrants further exploration for potential immunotherapy of MPE.
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DOI：
10.1164/rccm.200504-588oc
发表时间：
2005-12-01
影响因子：
24.7
作者：
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