Predicting immunoglobulin resistance in Kawasaki disease: an assessment of neutrophil to lymphocyte platelet ratio.
Predicting immunoglobulin resistance in Kawasaki disease: an assessment of neutrophil to lymphocyte platelet ratio.
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预测川崎病的免疫球蛋白抵抗：中性粒细胞与淋巴细胞血小板比率的评估
DOI：
10.1186/s13052-022-01400-9
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发表时间：
2022-12-30
影响因子：
3.6
通讯作者：
Qin, Yiming
中科院分区：
文献类型：
--
作者：
Lu, Yuyao;Tang, Yunjia;Wang, Bo;Li, Xuan;Xu, Qiuqin;Chu, Hui;Lv, Haitao;Lu, Meihua;Qin, Yiming
关键词：
背景川崎病（KD）是一种病因不明的急性发热性疾病，静脉注射免疫球蛋白（IVIG）耐药的预测因子近几十年来已得到广泛研究。据报道，中性粒细胞与淋巴细胞血小板比率（NLPR）与许多疾病的结果相关。但其与IVIG耐药的关系尚未探讨。方法对2019年1月至2020年12月苏州大学儿童医院诊断为KD的患者的医疗资料进行回顾性分析。根据 NLPR 将患者分为三组。使用Logistic回归分析NLPR与IVIG耐药性之间的关联。使用受限立方脊柱来展示这种关系。还进行了敏感性分析和亚组分析。结果本研究共纳入803例患者（61.8%为男性；中位年龄：24个月）。 74 名 (9.2%) 患者出现 IVIG 耐药。多变量调整分析显示，较高的 NLPR（比值比 [95% 置信区间]：1.12 [1.00-1.24]）是 IVIG 耐药性的独立预测因子，敏感性分析进一步证实了这一点。 NLPR 和 IVIG 耐药的相关性不因年龄、性别、CAL 或 IVIG 起始天数 ≤ 4 改变。结论 NLPR 可能是 IVIG 耐药 KD 患者的一个有价值的预后标志物。
BackgroundKawasaki disease (KD) is an acute febrile illness of unknown etiology and predictors for intravenous immunoglobulin (IVIG) resistance have been widely explored in recent decades. Neutrophil to lymphocyte platelet ratio (NLPR) was reported to be associated with the outcomes in many diseases. However, its relationship with IVIG resistance has not be explored.MethodsThe medical data of patients diagnosed with KD in Children’s Hospital of Soochow University between January 2019 and December 2020 were retrospectively reviewed and analyzed. Patients were trisected into three groups based on NLPR. Logistics regression was used to analyze the association between NLPR and IVIG resistance. Restricted cubic spine was used to exhibit the relationship. Sensitivity analysis and subgroup analysis were also carried out.ResultsA total of 803 patients were included in the present study (61.8% males; median age: 24 months). IVIG resistance occurred in 74 (9.2%) patients. Multivariable-adjusted analyses revealed higher NLPR (odds ratio [95% confidence interval]: 1.12 [1.00-1.24]) was an independent predictor of IVIG resistance, which was strengthened by sensitivity analyses. The association of NLPR and IVIG resistance was not modified by age, sex, CALs, or days of IVIG initiation ≤ 4.ConclusionNLPR may be a valuable prognostic marker in KD patients with IVIG resistance.
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作者：
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影响因子：
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作者：
Qian W;Tang Y;Yan W;Sun L;Lv H
通讯作者：
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