Differential regulation of spontaneous and evoked neurotransmitter release at central synapses.
Differential regulation of spontaneous and evoked neurotransmitter release at central synapses.
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DOI：
10.1016/j.conb.2011.01.007
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发表时间：
2011-04
影响因子：
5.7
通讯作者：
Kavalali ET
中科院分区：
文献类型：
--
作者：
Ramirez DM;Kavalali ET
最近的研究已经开始仔细研究突触前机制和囊泡群，它们引起动作电位诱发和自发形式的神经递质释放。在一些情况下，这项工作产生了意想不到的结果，支持了诱发和自发神经递质释放的调节、机制、突触后目标和可能的突触前起源不同的观点。此外，以不同方式影响自发释放和诱发释放的监管途径清单正在迅速增加。这些发现挑战了我们关于诱发神经传递和自发神经传递之间关系的经典观点。与同样抑制或增强所有形式的神经递质释放的充分表征的神经调节途径相反，专门控制自发释放的分子底物仍不清楚。在这篇综述中，我们概述了可能构成不同形式神经传递差异调节的可能机制，并帮助解复用复杂的神经元信号并在其突触后目标处产生并行信号事件。
Recent studies have begun to scrutinize the presynaptic machinery and vesicle populations that give rise to action potential evoked and spontaneous forms of neurotransmitter release. In several cases this work produced unexpected results which lend support to the notion that regulation, mechanisms, postsynaptic targets and possibly presynaptic origins of evoked and spontaneous neurotransmitter release differ. Furthermore, the list of regulatory pathways that impact spontaneous and evoked release in a divergent manner is rapidly growing. These findings challenge our classical views on the relationship between evoked and spontaneous neurotransmission. In contrast to the well-characterized neuromodulatory pathways that equally suppress or augment all forms of neurotransmitter release, molecular substrates specifically controlling spontaneous release remain unclear. In this review, we outline possible mechanisms that may underlie the differential regulation of distinct forms of neurotransmission and help demultiplex complex neuronal signals and generate parallel signaling events at their postsynaptic targets.
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