A locus coeruleus to dentate gyrus noradrenergic circuit modulates aversive contextual processing.
A locus coeruleus to dentate gyrus noradrenergic circuit modulates aversive contextual processing.
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DOI：
10.1016/j.neuron.2021.05.006
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发表时间：
2021-07-07
期刊：
影响因子：
16.2
通讯作者：
Bruchas MR
中科院分区：
文献类型：
--
作者：
Seo DO;Zhang ET;Piantadosi SC;Marcus DJ;Motard LE;Kan BK;Gomez AM;Nguyen TK;Xia L;Bruchas MR
Dysregulation in contextual processing is believed to affect several forms of psychopathology, such as post-traumatic stress disorder (PTSD). The dentate gyrus (DG), a subregion of the hippocampus, is thought to be an important brain region for disambiguating new experiences from prior experiences. Noradrenergic (NE) neurons in the locus coeruleus (LC) are more tonically active during stressful events and send dense projections to the DG, yet an understanding of their function in DG-dependent contextual discrimination has not been established. Here, we isolate a key function of the LC-NE-DG circuit in contextual aversive generalization using selective manipulations and in vivo single cell calcium imaging. We report that activation of LC-NE neurons and terminal activity results in contextual generalization. We found these effects required β-adrenergic-mediated modulation of hilar interneurons to ultimately promote aversive generalization, suggesting that disruption of noradrenergic tone may serve as an important avenue for treating stress-induced disorders. Seo and Zhang et al. implicate a locus coeruleus to dentate gyrus noradrenergic circuit in modulation of aversive contextual processing. Disrupted contextual processing occurs in several psychopathologies, including post-traumatic stress disorder (PTSD). Elucidating the role of noradrenergic modulation of behavior can yield more effective treatments for stress disorders.
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DOI：
10.1126/science.1247485
发表时间：
2014-02-21
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Lovett-Barron M;Kaifosh P;Kheirbek MA;Danielson N;Zaremba JD;Reardon TR;Turi GF;Hen R;Zemelman BV;Losonczy A
通讯作者：
Losonczy A
影响因子：
34.7
作者：
Arnsten, Amy F. T.
通讯作者：
Arnsten, Amy F. T.
影响因子：
25
作者：
Mahn M;Prigge M;Ron S;Levy R;Yizhar O
通讯作者：
Yizhar O
DOI：
10.1007/bf00334281
发表时间：
1967-01-01
期刊：
ZEITSCHRIFT FUR ZELLFORSCHUNG UND MIKROSKOPISCHE ANATOMIE
影响因子：
--
作者：
BLACKSTAD, TW;FUXE, K;HOKFELT, T
通讯作者：
HOKFELT, T
影响因子：
16.6
作者：
Jimenez, Jessica C.;Berry, Jack E.;Hen, Rene
通讯作者：
Hen, Rene