The balance between adhesion and contraction during cell division.

The balance between adhesion and contraction during cell division.
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DOI:
10.1016/j.ceb.2018.09.001
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发表时间:
2019-03
影响因子:
7.5
通讯作者:
Burnette DT
Burnette DT
中科院分区:
生物学2区
文献类型:
--
作者:
Taneja N;Rathbun L;Hehnly H;Burnette DT

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分裂的能力是活细胞的基本属性。细胞分裂的3D方向对于胚胎发生、组织组织和结构的维持以及控制细胞命运至关重要。有丝分裂纺锤体沿着细胞最长轴的位置是有丝分裂中心体延伸到细胞皮质的微管群之间的形状感知机制,这一点引起了人们的广泛关注。然而,细胞皮层的收缩力也可能在决定分裂后子细胞的最终位置方面发挥决定性作用。在这篇综述中,我们讨论了最近的文献,描述了这些收缩力的作用,以及如何这些力量可以平衡有丝分裂粘附复合物。
The ability to divide is a fundamental property of a living cell. The 3D orientation of cell division is essential for embryogenesis, maintenance of tissue organization and architecture, as well as controlling cell fate. Much attention has been placed on the mitotic spindle’s role in placing itself along the cell’s longest axis, where a shape sensing mechanism between a population of microtubules extending from mitotic centrosomes to the cell cortex occurs. However, contractile forces at the cell cortex also likely play a decisive role in determining the final placement of daughter cells following division. In this review, we discuss recent literature that describes the role of these contractile forces and how these forces could be balanced by mitotic adhesion complexes.
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