The gut peptide Reg3g links the small intestine microbiome to the regulation of energy balance, glucose levels, and gut function.
The gut peptide Reg3g links the small intestine microbiome to the regulation of energy balance, glucose levels, and gut function.
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DOI：
10.1016/j.cmet.2022.09.024
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发表时间：
2022-11-01
期刊：
影响因子：
29
通讯作者：
Seeley, Randy J.
中科院分区：
文献类型：
--
作者：
Shin, Jae Hoon;Bozadjieva-Kramer, Nadejda;Shao, Yikai;Lyons-Abbott, Sally;Rupp, Alan C.;Sandoval, Darleen A.;Seeley, Randy J.
改变肠道微生物组的组成是肠道适应各种环境的重要组成部分，这与包括肥胖和2型糖尿病在内的各种代谢疾病有关，但微生物群影响宿主生理学的机制仍然存在争议。在这里，我们发现，这两种饮食高的可发酵纤维菊粉和垂直袖状胃切除术增加肠道表达和循环水平的抗菌肽Reg3g。此外，这些操作对肠道功能、能量平衡和葡萄糖调节的许多有益作用在Reg3g敲除小鼠中不存在。外周施用Reg3g的各种制剂改善了葡萄糖耐量，并且这种作用依赖于胰腺中的推定受体Extl3。这些数据表明，Reg3g既在管腔内起作用，又作为肠道激素将肠道微生物组与宿主生理学的各个方面联系起来，这些方面可以用于新的治疗策略。Shin等人发现，手术和饮食肠道操作都增加了肠道肽Reg3g，并且需要Reg3g对体重、葡萄糖水平和肠道功能产生有益作用。Reg3g还可能充当肠道激素，因为全身给药通过对胰腺的作用改善葡萄糖调节。
Changing composition of the gut microbiome is an important component of the gut adaptation to various environments, which have been implicated in various metabolic diseases including obesity and type 2 diabetes but the mechanisms by which the microbiota influence host physiology remain contentious. Here we find that both diets high in the fermentable fiber inulin and vertical sleeve gastrectomy increase intestinal expression and circulating levels of the anti-microbial peptide Reg3g. Moreover, a number of beneficial effects of these manipulations on gut function, energy balance and glucose regulation are absent in Reg3g knockout mice. Peripheral administration of various preparations of Reg3g improves glucose tolerance and this effect is dependent on the putative receptor Extl3 in the pancreas. These data suggest Reg3g acts both within the lumen and as a gut hormone to link the intestinal microbiome to various aspects of host physiology that may be leveraged for novel treatment strategies. Shin et al. find that both surgical and dietary gut manipulations increase the gut peptide Reg3g and require Reg3g for their beneficial effects on body weight, glucose levels and gut function. Reg3g may also act as a gut hormone since systemic administration improves glucose regulation via actions on the pancreas.
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DOI：
10.1038/nrmicro3552
发表时间：
2016-01
期刊：
Nature reviews. Microbiology
影响因子：
--
作者：
Donaldson GP;Lee SM;Mazmanian SK
通讯作者：
Mazmanian SK
影响因子：
48
作者：
Callahan BJ;McMurdie PJ;Rosen MJ;Han AW;Johnson AJ;Holmes SP
通讯作者：
Holmes SP
影响因子：
16.9
作者：
Courcoulas, Anita P.;Goodpaster, Bret H.;Eagleton, Jessie K.;Belle, Steven H.;Kalarchian, Melissa A.;Lang, Wei;Toledo, Frederico G. S.;Jakicic, John M.
通讯作者：
Jakicic, John M.
DOI：
10.1152/ajpendo.00469.2013
发表时间：
2014-02-01
影响因子：
5.1
作者：
Chambers, Adam P.;Smith, Eric P.;Sandoval, Darleen A.
通讯作者：
Sandoval, Darleen A.
影响因子：
15.9
作者：
Fujisaka, Shiho;Ussar, Siegfried;Kahn, C. Ronald
通讯作者：
Kahn, C. Ronald