Age and gene overexpression interact to abolish nesting behavior in Tg2576 amyloid precursor protein (APP) mice.
Age and gene overexpression interact to abolish nesting behavior in Tg2576 amyloid precursor protein (APP) mice.
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DOI：
10.1016/j.bbr.2010.08.033
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发表时间：
2011-01-01
影响因子：
2.7
通讯作者：
Wilson, Donald A.
中科院分区：
文献类型：
--
作者：
Wesson, Daniel W.;Wilson, Donald A.
阐明社会行为的调节因素对于理解行为的神经基础以及开发在行为紊乱情况下改善行为的方法至关重要。此处的研究源于这样一个观察结果：阿尔茨海默病小鼠模型Tg2576过度表达淀粉样β前体蛋白基因（APP）的人类突变，当在其饲养笼中提供纸巾时无法构建巢穴。使用市售棉质筑巢材料进行的实验也发现了类似结果。额外的实验表明，在APP小鼠中基因型效应随年龄逐渐受到调节，但在野生型（WT）小鼠中并非如此。在任何组中，性别对筑巢行为都没有影响。最后，这种效应与环境温度无关——即使处于寒冷环境中，APP小鼠也无法构建巢穴，而WT小鼠可以。这些结果表明APP基因在亲和行为中起作用，并结合APP基因突变所特有的紊乱以及情感功能障碍（包括阿尔茨海默病）进行了讨论。
Elucidating the modulators of social behavioral is important in understanding the neural basis of behavior and in developing methods to enhance behavior in cases of disorder. The work here stems from the observation that the Alzheimer’s disease mouse model Tg2576, overexpressing human mutations of the amyloid-β precursor protein gene (APP) fails to construct nests when supplied paper towels in their home cages. Experiments using commercially available cotton nesting material found similar results. Additional experiments revealed that the genotype effect is progressively modulated by age in APP mice but not their WT counterparts. There was no effect of sex on nesting behavior in any group. Finally, this effect was independent of ambient temperature – even when subjected to a cold environment APP mice fail to build nests whereas WT mice do. These results suggest that the APP gene plays a role in affiliative behaviors and are discussed in relation to disorders characteristic of mutations in the APP gene and in affective dysfunction, including Alzheimer’s disease.
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影响因子：
2.5
作者：
Filali, M.;Lalonde, R.;Rivest, S.
通讯作者：
Rivest, S.
影响因子：
2.9
作者：
King, DL;Arendash, GW
通讯作者：
Arendash, GW
影响因子：
2.9
作者：
Lalonde, R;Lewis, TL;Fukuchi, K
通讯作者：
Fukuchi, K
DOI：
10.1073/pnas.0908953107
发表时间：
2010-01-26
影响因子：
11.1
作者：
Jiang, Ying;Mullaney, Kerry A.;Nixon, Ralph A.
通讯作者：
Nixon, Ralph A.
影响因子：
2.6
作者：
BATCHELDER, P;LYNCH, CB;SCHNEIDER, JE
通讯作者：
SCHNEIDER, JE