Adiponectin gene and risk of colorectal cancer.
Adiponectin gene and risk of colorectal cancer.
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DOI：
10.1038/bjc.2011.259
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发表时间：
2011-08-09
影响因子：
8.8
通讯作者：
Gruber, S. B.
中科院分区：
文献类型：
--
作者：
Gornick, M. C.;Rennert, G.;Moreno, V.;Gruber, S. B.
基于结直肠癌和肥胖之间的潜在关联，脂联素通路的基因是结直肠癌风险的有趣候选者。然而，脂联素基因（ADIPOQ）的变异已被证明与结直肠癌的风险不一致。目前的研究试图通过检测几个单核苷酸多态性（snp）来评估这些发现，这些多态性之前是ADIPOQ基因全基因组关联研究的一部分。作为以色列一项基于人群的病例对照研究的一部分，研究人员还对1062名结直肠癌诊断患者和1062名年龄、性别和种族（犹太人或非犹太人）匹配的对照组进行了先前报道的风险变异rs266729的基因分型。没有证据表明ADIPOQ与结直肠癌风险之间存在关联。先前与结直肠癌风险降低相关的单核苷酸变异rs266729显示调整后的优势比为1.04；95%置信区间为0.88-1.23。SNP rs266729与德系犹太人后裔或以色列其他种族患者的结直肠癌没有很强的关联。
Genes of the adiponectin pathway are interesting candidates for colorectal cancer risk based on the potential association between colorectal cancer and obesity. However, variants of the adiponectin gene (ADIPOQ) have been demonstrated to be inconsistently associated with risk of colorectal cancer. The current study attempted to evaluate these findings by examining several single nucleotide polymorphisms (SNPs) that were previously genotyped as part of a genome-wide association study in the ADIPOQ gene. Genotyping was also performed for a previously reported risk variant, rs266729, in 1062 individuals with a diagnosis of colorectal cancer and 1062 controls matched on age, gender and ethnicity (Jewish or not Jewish) as part of a population-based case–control study in Israel. No evidence was found for an association between ADIPOQ and risk of colorectal cancer. The single nucleotide variant previously associated with decreased risk of colorectal cancer, rs266729, revealed an adjusted odds ratio of 1.04; 95% confidence interval, 0.88–1.23. The SNP, rs266729, was not strongly associated with colorectal cancer in patients of Ashkenazi Jewish descent or other ethnic groups in Israel.
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影响因子：
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通讯作者：
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作者：
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