Reversion of advanced Ebola virus disease in nonhuman primates with ZMapp.
Reversion of advanced Ebola virus disease in nonhuman primates with ZMapp.
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DOI：
10.1038/nature13777
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发表时间：
2014-10-02
期刊：
影响因子：
64.8
通讯作者：
Kobinger, Gary P.
中科院分区：
文献类型：
--
作者：
Qiu, Xiangguo;Wong, Gary;Audet, Jonathan;Bello, Alexander;Fernando, Lisa;Alimonti, Judie B.;Fausther-Bovendo, Hugues;Wei, Haiyan;Aviles, Jenna;Hiatt, Ernie;Johnson, Ashley;Morton, Josh;Swope, Kelsi;Bohorov, Ognian;Bohorova, Natasha;Goodman, Charles;Kim, Do;Pauly, Michael H.;Velasco, Jesus;Pettitt, James;Olinger, Gene G.;Whaley, Kevin;Xu, Bianli;Strong, James E.;Zeitlin, Larry;Kobinger, Gary P.
在没有获得批准的疫苗或治疗方法的情况下，埃博拉疫情的管理仅限于姑息治疗和防止传播的屏障方法。然而，这些方法尚未结束2014年埃博拉病毒在西非长期存在后的爆发。在这里，我们表明，从两种先前的抗体混合物优化的单克隆抗体（ZMapp™）的组合能够在攻击后5天开始治疗时拯救100%的恒河猴。在ZMapp™干预之前，高热、病毒血症以及血细胞计数和化学异常在许多动物中是明显的。晚期疾病，如肝酶升高，粘膜损伤和全身性瘀点，可以逆转，导致完全恢复。ELISA和中和抗体测定表明ZMapp™与埃博拉的几内亚变体交叉反应。ZMapp™目前超过了所有以前描述的其他疗法的疗效，结果保证了这种鸡尾酒的进一步发展，以供临床使用。
Without an approved vaccine or treatment, Ebola outbreak management has been limited to palliative care and barrier methods to prevent transmission. These approaches, however, have yet to end the 2014 outbreak of Ebola after its prolonged presence in West Africa. Here we show that a combination of monoclonal antibodies (ZMapp™), optimized from two previous antibody cocktails, is able to rescue 100% of rhesus macaques when treatment is initiated up to 5 days post-challenge. High fever, viremia, and abnormalities in blood count and chemistry were evident in many animals before ZMapp™ intervention. Advanced disease, as indicated by elevated liver enzymes, mucosal hemorrhages and generalized petechia could be reversed, leading to full recovery. ELISA and neutralizing antibody assays indicate that ZMapp™ is cross-reactive with the Guinean variant of Ebola. ZMapp™ currently exceeds all previous descriptions of efficacy with other therapeutics, and results warrant further development of this cocktail for clinical use.
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影响因子：
17.1
作者：
Qiu, Xiangguo;Audet, Jonathan;Kobinger, Gary P.
通讯作者：
Kobinger, Gary P.
DOI：
10.1073/pnas.0606631103
发表时间：
2006-10-03
影响因子：
11.1
作者：
Giritch, Anatoli;Marillonnet, Sylvestre;Gleba, Yuri
通讯作者：
Gleba, Yuri
影响因子：
4.6
作者：
Qiu, Xiangguo;Audet, Jonathan;Kobinger, Gary P.
通讯作者：
Kobinger, Gary P.
DOI：
10.1016/s0140-6736(10)60357-1
发表时间：
2010-05-29
期刊：
Lancet (London, England)
影响因子：
--
作者：
Geisbert TW;Lee AC;Robbins M;Geisbert JB;Honko AN;Sood V;Johnson JC;de Jong S;Tavakoli I;Judge A;Hensley LE;Maclachlan I
通讯作者：
Maclachlan I
影响因子：
82.9
作者：
Warren, Travis K.;Warfield, Kelly L.;Bavari, Sina
通讯作者：
Bavari, Sina