Sporadic hand, foot, and mouth disease cases associated with non-C4 enterovirus 71 strains in Xiamen, China, from 2009 to 2018.
Sporadic hand, foot, and mouth disease cases associated with non-C4 enterovirus 71 strains in Xiamen, China, from 2009 to 2018.
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2009 - 2018年中国厦门与非c4肠病毒71株相关的散发手足口病病例
DOI：
10.1007/s00705-021-05097-9
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发表时间：
2021-08
影响因子：
2.7
通讯作者：
Xia N
中科院分区：
文献类型：
--
作者：
Chen M;He S;Yan Q;Zhang J;Li C;Su X;Zhang S;Li T;Ge S;Chen M;Zhang J;Xia N
肠病毒71型（EV71）在幼儿中引起了大量手足口病（HFMD）流行，EV71感染是严重手足口病病例和死亡的主要原因。在中国大陆，非c4型EV71病毒株的流行情况和危险因素尚不清楚。在本研究中，我们对厦门市10年手足口病流行病学监测期间的非c4菌株进行了监测。采用rt -巢式PCR扩增EV71株5′utr和VP1编码区，并对其进行测序。2009-2018年共鉴定出32株非c4型EV71菌株。本研究为手足口病疫苗和诊断试剂的开发以及手足口病防控政策的制定提供了重要的信息。在线版本包含补充材料，可在10.1007/s00705-021-05097-9获得。
Enterovirus 71 (EV71) has caused large hand, foot, and mouth disease (HFMD) epidemics among young children, and EV71 infection is the leading cause of severe HFMD cases and deaths. In mainland China, the prevalence and risk factors of non-C4 EV71 strains are still unclear. In this study, we monitored non-C4 strains over a 10-year HFMD epidemiological surveillance period in Xiamen. The 5’UTR and VP1 coding region of EV71 strains were amplified by RT-nested PCR and sequenced. Thirty-two non-C4 EV71 strains were identified during 2009-2018. This study provides important information about the prevalence of EV71 in China that will be applicable for development of vaccines and diagnostic reagents as well as establishment of policies for HFMD prevention and control. The online version contains supplementary material available at 10.1007/s00705-021-05097-9.
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影响因子：
3.1
作者：
Ge, Shengxiang;Yan, Qiang;Xia, Ningshao
通讯作者：
Xia, Ningshao
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3.7
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Wu J
影响因子：
9.4
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Huang, Sheng-Wen;Hsu, Yun-Wei;Wang, Jen-Ren
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Wang, Jen-Ren
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3.7
作者：
Donato, Celeste;Le Thi Hoi;Vijaykrishna, Dhanasekaran
通讯作者：
Vijaykrishna, Dhanasekaran
影响因子：
56.3
作者：
Xing, Weijia;Liao, Qiaohong;Viboud, Cecile;Zhang, Jing;Sun, Junling;Wu, Joseph T.;Chang, Zhaorui;Liu, Fengfeng;Fang, Vicky J.;Zheng, Yingdong;Cowling, Benjamin J.;Varma, Jay K.;Farrar, Jeremy J.;Leung, Gabriel M.;Yu, Hongjie
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Yu, Hongjie