Common genetic variants in the 8q24 region and risk of papillary thyroid cancer.
Common genetic variants in the 8q24 region and risk of papillary thyroid cancer.
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DOI：
10.1002/lary.23209
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发表时间：
2012-05
期刊：
影响因子：
2.6
通讯作者：
Sigurdson, Alice J.
中科院分区：
文献类型：
--
作者：
Neta, Gila;Yu, Chu-Ling;Brenner, Alina;Gu, Fangyi;Hutchinson, Amy;Pfeiffer, Ruth;Sturgis, Erich M.;Xu, Li;Linet, Martha S.;Alexander, Bruce H.;Chanock, Stephen;Sigurdson, Alice J.
从全基因组扫描中鉴定的8q24染色体区域的单核苷酸多态性（SNP）与几种癌症的风险相关，包括乳腺癌（rs1562430），前列腺癌和结肠癌（rs1447295和rs6983267）。在26个甲状腺乳头状癌（PTC）家族中进行的全基因组扫描也发现了8q24中的易感基因座，这支持了对该染色体区域与散发性PTC风险相关的更密切评估。我们在一项病例对照研究中评估了8q24染色体区域120.91 Mb和128.78 Mb之间的157个标签SNP（包括rs1562430，rs1447295和rs6983267），该研究包括344例PTC病例和452例年龄和性别频率匹配的对照。我们使用逻辑回归来估计优势比，并计算PTC与感兴趣的基因型的线性趋势的P值。为了解释多重比较，我们应用了错误发现率（FDR）方法。我们没有发现rs1562430、rs1447295或rs6983267与PTC风险之间存在显著关联。我们发现一个SNP（rs4733616）与PTC风险相关，P = 0.003，其他12个SNP与PTC风险相关，P < 0.05。然而，在FDR校正后，没有SNP保持显著性。我们的研究结果不支持8q24染色体区域的SNPs与散发性PTC风险之间存在强关联，但可能存在几个影响较小的SNPs。
Single nucleotide polymorphisms (SNPs) in the 8q24 chromosomal region identified from genome-wide scans have been associated with risk of several cancers including breast (rs1562430), prostate and colon (rs1447295 and rs6983267). A genome-wide scan in 26 families with papillary thyroid cancer (PTC) also found susceptibility loci in 8q24, supporting a closer evaluation of this chromosomal region in relation to risk of sporadic PTC. We evaluated 157 tag SNPs in the 8q24 chromosomal region between 120.91 Mb and 128.78 Mb (including rs1562430, rs1447295, and rs6983267) in a case-control study of 344 PTC cases and 452 age and gender frequency-matched controls. We used logistic regression to estimate odds ratios and compute P-values of linear trend for PTC with genotypes of interest. To account for multiple comparisons, we applied the false discovery rate (FDR) method. We did not find a significant association between rs1562430, rs1447295, or rs6983267, and PTC risk. We found that one SNP (rs4733616) was associated with PTC risk at P = 0.003, and twelve other SNPs were associated with PTC risk at P < 0.05. However, no SNPs remained significant after FDR correction. Our findings do not support a strong association between SNPs in the 8q24 chromosomal region and risk of sporadic PTC but several SNPs with small effects might exist.
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