Edited magnetic resonance spectroscopy detects an age-related decline in brain GABA levels.
Edited magnetic resonance spectroscopy detects an age-related decline in brain GABA levels.
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DOI：
10.1016/j.neuroimage.2013.04.012
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发表时间：
2013-09
期刊：
影响因子：
5.7
通讯作者：
Barker, Peter B.
中科院分区：
文献类型：
--
作者：
Gao, Fei;Edden, Richard A. E.;Li, Muwei;Puts, Nicolaas A. J.;Wang, Guangbin;Liu, Cheng;Zhao, Bin;Wang, Huiquan;Bai, Xue;Zhao, Chen;Wang, Xin;Barker, Peter B.
γ-氨基丁酸（GABA）是大脑中主要的抑制性神经递质。虽然使用编辑的质子磁共振波谱（1H-MRS）测量人脑中的GABA水平已经建立了一段时间，但尚未确定正常人脑中区域GABA水平如何随年龄变化。在这项研究中，招募了49名健康男性和51名健康女性，年龄在20至76岁之间，并在3特斯拉下记录了J-差异编辑光谱，以确定年龄对GABA水平的影响，并调查内侧额叶和顶叶区域中GABA是否存在区域和性别差异。因为使用这些实验参数在3.02 ppm处检测到的信号也预期包含来自大分子（MM）和高肌肽两者的贡献，所以在本研究中，信号被标记为GABA+而不是GABA。GABA+/Cr：额区，r =-0.68，p < 0.001，顶区，r =-0.54，p <0.001; GABA+/NAA：额区，r =-0.58，p <0.001，顶区，r =-0.49，p < 0.001）。女性额叶区GABA+随年龄增长的下降速度比男性快。GABA的可测量下降的证据对于考虑与正常衰老相关的认知下降的神经化学基础是重要的。
Gamma-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the brain. Although measurements of GABA levels in vivo in the human brain using edited proton magnetic resonance spectroscopy (1H-MRS) have been established for some time, it is has not been established how regional GABA levels vary with age in the normal human brain. In this study, 49 healthy men and 51 healthy women aged between 20 and 76 years were recruited and J-difference edited spectra were recorded at 3 Tesla to determine the effect of age on GABA levels, and to investigate whether there are regional and gender differences in GABA in mesial frontal and parietal regions. Because the signal detected at 3.02 ppm using these experimental parameters is also expected to contain contributions from both macromolecules (MM) and homocarnosine, in this study the signal is labeled GABA+ rather than GABA. Significant negative correlations were observed between age and GABA+ in both regions studied (GABA+/Cr: frontal region, r = -0.68, p< 0.001, parietal region, r = -0.54, p< 0.001; GABA+/NAA: frontal region, r = -0.58, p< 0.001, parietal region, r = -0.49, p< 0.001). The decrease in GABA+ with age in the frontal region was more rapid in women than men. Evidence of a measureable decline in GABA is important in considering the neurochemical basis of the cognitive decline that is associated with normal aging.
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DOI：
10.1016/j.cub.2010.09.003
发表时间：
2010-10-12
期刊：
Current biology : CB
影响因子：
--
作者：
Boy F;Evans CJ;Edden RA;Singh KD;Husain M;Sumner P
通讯作者：
Sumner P
影响因子：
3.9
作者：
CASPARY, DM;MILBRANDT, JC;HELFERT, RH
通讯作者：
HELFERT, RH
影响因子：
1.8
作者：
Betts, Lisa R.;Sekuler, Allison B.;Bennett, Patrick J.
通讯作者：
Bennett, Patrick J.
影响因子：
5.7
作者：
Grachev, ID;Apkarian, AV
通讯作者：
Apkarian, AV
影响因子：
--
作者：
Epperson, CN;Haga, K;Krystal, JH
通讯作者：
Krystal, JH