Expression of the epithelial-mesenchymal transition-related proteins and their clinical significance in lung adenocarcinoma.
Expression of the epithelial-mesenchymal transition-related proteins and their clinical significance in lung adenocarcinoma.
复制标题
上皮间质转变相关蛋白的表达及其在肺腺癌中的临床意义。
DOI：
10.1186/1746-1596-8-89
复制
发表时间：
2013-05-24
影响因子：
2.6
通讯作者：
Fan X
中科院分区：
文献类型：
--
作者：
Shi Y;Wu H;Zhang M;Ding L;Meng F;Fan X
上皮-间充质转化（epithelial -mesenchymal transition， EMT）被定义为极化上皮细胞向迁移成纤维样细胞表型的转换。已知EMT参与多种癌症的进展和转移。目的是评估emt相关蛋白的改变是否与肺腺癌的临床病理特征和预后相关。采用组织阵列法免疫组化检测95例肺腺癌组织中细胞角蛋白、E-cadherin、TTF-1、β-catenin、vimentin、Snail、Twist、CD44等emt相关蛋白的表达。此外，将临床病理特征和生存率与emt相关蛋白的表达进行比较。在肺腺癌中观察到上皮蛋白的缺失和/或间充质蛋白的表达。这些蛋白的改变分别与细胞分化不良和患者预后不良有关。根据emt相关蛋白的改变数量将受试者分为两组。大量emt相关蛋白的改变与不良结果显著相关。多因素分析显示，较多的emt相关蛋白改变与预后不良独立相关。emt相关蛋白的改变数量是预测肺腺癌患者总生存率的重要预后指标。所产生的信息将对肺腺癌患者的预后有价值。本文的虚拟幻灯片可以在这里找到：http://www.diagnosticpathology.diagnomx.eu/vs/1007838329872974
Epithelial-mesenchymal transition (EMT) is defined as switching of polarized epithelial cells to a migratory fibroblastoid phenotype. EMT is known to be involved in the progression and metastasis of various cancers. The aim was to evaluate that whether EMT-related proteins' alterations are associated with clinicopathological features and prognosis in lung adenocarcinoma. The expression of EMT-related proteins including cytokeratin, E-cadherin, TTF-1, β-catenin, vimentin, Snail, Twist, CD44 was evaluated by immunohistochemistry using a tissue array method in the lung adenocarcinoma tissues of 95 patients. In addition, clinicopathological characteristics and survival were compared with the expression of EMT-related proteins. Loss of epithelial proteins and/or acquisition of the expression of mesenchymal proteins were observed in lung adenocarcinoma. These proteins’ alteration was associated with poor cell differentiation and poor patients’ outcome, respectively. Subjects were divided into two groups according to the number of EMT-related proteins’ alteration. A higher number of EMT-related proteins’ alteration was found to be significantly associated with unfavorable outcome. Multivariate analysis showed that a higher number of EMT-related proteins’ alteration was independently associated with poor prognosis. The number of EMT-related proteins’ alteration is a significant prognostic marker to predict overall survival in patients with lung adenocarcinoma. The information generated will be valuable for the prognosis of patients with lung adenocarcinoma. The virtual slides for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/1007838329872974
登录
查看更多内容
影响因子：
50.3
作者：
Moody, SE;Perez, D;Chodosh, LA
通讯作者：
Chodosh, LA
影响因子：
8
作者：
Jechlinger, M;Grunert, S;Kraut, N
通讯作者：
Kraut, N
DOI：
10.1083/jcb.200601018
发表时间：
2006-03-27
期刊：
The Journal of cell biology
影响因子：
--
作者：
Lee JM;Dedhar S;Kalluri R;Thompson EW
通讯作者：
Thompson EW
影响因子：
11.2
作者：
Chiou, Shih-Hwa;Wang, Mong-Lien;Wu, Cheng-Wen
通讯作者：
Wu, Cheng-Wen
影响因子：
11.2
作者：
Saito, Roy-Akira;Watabe, Tetsuro;Miyazono, Kohei
通讯作者：
Miyazono, Kohei