The epithelial-mesenchymal transition: new insights in signaling, development, and disease.
The epithelial-mesenchymal transition: new insights in signaling, development, and disease.
复制标题
DOI：
10.1083/jcb.200601018
复制
发表时间：
2006-03-27
期刊：
影响因子：
--
通讯作者：
Thompson EW
中科院分区：
文献类型：
--
作者：
Lee JM;Dedhar S;Kalluri R;Thompson EW
上皮细胞向间充质细胞的转化对后生动物胚胎发生和器官发育的定义结构特征至关重要。目前对这一过程的兴趣被描述为上皮-间充质转化（EMT），源于其发育的重要性及其在几种成人病理中的参与。从最近在加拿大温哥华举行的EMT会议（2005年10月1-3日）的出席情况来看，目前对EMT的兴趣和研究处于较高水平。这次会议是第二次国际EMT会议，由EMT国际协会主办，第一次会议于2003年10月在澳大利亚昆士兰州的道格拉斯港举行。EMT国际协会成立于2002年，旨在为那些对EMT及其逆转过程，间充质-上皮转化感兴趣的人提供一个国际机构，最重要的是，将那些在发育，癌症，纤维化和病理学方面从事EMT工作的人聚集在一起。最近在温哥华举行的会议继续讨论这些主题。在温哥华会议上的讨论跨越了几个研究领域，包括EMT的信号通路激活和相关的转录因子和基因靶点。还详细介绍了EMT的基本细胞生物学及其在癌症和纤维化中的作用，以及识别新的标记物以促进体内EMT的观察。这是特别重要的，因为EMT在瘤形成期间的潜在贡献是激烈的科学辩论的主题（Tarin，D.，E.W. Thompson和D.F.纽格林2005. Cancer Res. 65：5996-6000; Thompson，E.W.，D.F. Newgreen和D.塔林2005. Cancer Res. 65：5991-5995）。
The conversion of an epithelial cell to a mesenchymal cell is critical to metazoan embryogenesis and a defining structural feature of organ development. Current interest in this process, which is described as an epithelial–mesenchymal transition (EMT), stems from its developmental importance and its involvement in several adult pathologies. Interest and research in EMT are currently at a high level, as seen by the attendance at the recent EMT meeting in Vancouver, Canada (October 1–3, 2005). The meeting, which was hosted by The EMT International Association, was the second international EMT meeting, the first being held in Port Douglas, Queensland, Australia in October 2003. The EMT International Association was formed in 2002 to provide an international body for those interested in EMT and the reverse process, mesenchymal–epithelial transition, and, most importantly, to bring together those working on EMT in development, cancer, fibrosis, and pathology. These themes continued during the recent meeting in Vancouver. Discussion at the Vancouver meeting spanned several areas of research, including signaling pathway activation of EMT and the transcription factors and gene targets involved. Also covered in detail was the basic cell biology of EMT and its role in cancer and fibrosis, as well as the identification of new markers to facilitate the observation of EMT in vivo. This is particularly important because the potential contribution of EMT during neoplasia is the subject of vigorous scientific debate (Tarin, D., E.W. Thompson, and D.F. Newgreen. 2005. Cancer Res. 65:5996–6000; Thompson, E.W., D.F. Newgreen, and D. Tarin. 2005. Cancer Res. 65:5991–5995).
登录
查看更多内容
影响因子：
10.5
作者：
Brembeck, FH;Schwarz-Romond, T;Birchmeier, W
通讯作者：
Birchmeier, W
DOI：
10.1083/jcb.200403043
发表时间：
2004-12-20
期刊：
The Journal of cell biology
影响因子：
--
作者：
Chu YS;Thomas WA;Eder O;Pincet F;Perez E;Thiery JP;Dufour S
通讯作者：
Dufour S
影响因子：
21.3
作者：
Ezratty, EJ;Partridge, MA;Gundersen, GG
通讯作者：
Gundersen, GG
影响因子：
5.3
作者：
Giri, DK;Ali-Seyed, M;Hung, MC
通讯作者：
Hung, MC
影响因子：
56.9
作者：
Chen, CS;Mrksich, M;Ingber, DE
通讯作者：
Ingber, DE