Curcumin attenuates cerebral edema following traumatic brain injury in mice: a possible role for aquaporin-4?
Curcumin attenuates cerebral edema following traumatic brain injury in mice: a possible role for aquaporin-4?
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DOI：
10.1111/j.1471-4159.2010.06630.x
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发表时间：
2010-05
影响因子：
4.7
通讯作者：
Dhandapani KM
中科院分区：
文献类型：
--
作者：
Laird MD;Sukumari-Ramesh S;Swift AE;Meiler SE;Vender JR;Dhandapani KM
创伤性脑损伤是一种毁灭性的神经损伤，与显著的发病率和死亡率相关。用于限制脑水肿（颅内高压升高和临床预后不良的一个原因）的医学疗法在很大程度上是无效的，这强调了对新治疗方法的需求。在本研究中，姜黄素（75、150毫克/千克）预处理或伤后30分钟给予300毫克/千克处理，可显著降低小鼠中度可控皮质撞击后的脑含水量并改善神经功能预后。姜黄素的保护作用与损伤后白细胞介素 - 1β（一种促炎细胞因子）在挫伤周围的急性表达显著减弱有关。姜黄素还逆转了水通道蛋白 - 4的诱导，水通道蛋白 - 4是一种与头部创伤后细胞水肿发展有关的星形胶质细胞水通道。值得注意的是，姜黄素阻断了白细胞介素 - 1β诱导的培养星形胶质细胞中水通道蛋白 - 4的表达，这种作用至少部分是通过减少核因子κB的p50和p65亚基的激活来介导的。与这一观点一致的是，姜黄素优先减弱了挫伤周围星形胶质细胞中磷酸化p65的免疫反应性，并降低了胶质纤维酸性蛋白（一种反应性星形胶质细胞标志物）的表达。总体而言，这些数据表明，临床上可达到浓度的姜黄素可减少神经创伤后的胶质细胞激活和脑水肿，这一发现值得进一步研究。
Traumatic brain injury is a devastating neurological injury associated with significant morbidity and mortality. Medical therapies to limit cerebral edema, a cause of increased intracranial hypertension and poor clinical outcome, are largely ineffective, emphasizing the need for novel therapeutic approaches. In the present study, pre-treatment with curcumin (75, 150 mg/kg) or 30 minute post-treatment with 300 mg/kg significantly reduced brain water content and improved neurological outcome following a moderate controlled cortical impact in mice. The protective effect of curcumin was associated with a significant attenuation in the acute pericontusional expression of interleukin-1β, a pro-inflammatory cytokine, after injury. Curcumin also reversed the induction of aquaporin-4, an astrocytic water channel implicated in the development of cellular edema following head trauma. Notably, curcumin blocked IL-1β-induced aquaporin-4 expression in cultured astrocytes, an effect mediated, at least in part, by reduced activation of the p50 and p65 subunits of NFκB. Consistent with this notion, curcumin preferentially attenuated phosphorylated p65 immunoreactivity in pericontusional astrocytes and decreased the expression of glial fibrillary acidic protein, a reactive astrocyte marker. As a whole, these data suggest clinically-achievable concentrations of curcumin reduce glial activation and cerebral edema following neurotrauma, a finding which warrants further investigation.
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DOI：
10.1631/jzus.2005.b0033
发表时间：
2005-01-01
期刊：
Journal of Zhejiang University. Science. B
影响因子：
--
作者：
Hu, Hua;Yao, Hong-tian;Wei, Er-qing
通讯作者：
Wei, Er-qing
DOI：
10.1124/jpet.106.109876
发表时间：
2006-12-01
影响因子：
3.5
作者：
Hewett, Sandra J.;Silakova, Janna M.;Hewett, James A.
通讯作者：
Hewett, James A.
影响因子：
4.8
作者：
Dempsey, RJ;Baskaya, MK;Dogan, A
通讯作者：
Dogan, A
影响因子：
4.1
作者：
ALDRICH, EF;EISENBERG, HM;YOUNG, HF
通讯作者：
YOUNG, HF
影响因子：
4.8
作者：
Khan, MM;Hadman, M;Brann, DW
通讯作者：
Brann, DW