Quantitative susceptibility mapping (QSM) minimizes interference from cellular pathology in R2* estimation of liver iron concentration.
Quantitative susceptibility mapping (QSM) minimizes interference from cellular pathology in R2* estimation of liver iron concentration.
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DOI：
10.1002/jmri.26019
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发表时间：
2018-10
期刊：
影响因子：
--
通讯作者：
Wang Y
中科院分区：
文献类型：
--
作者：
Li J;Lin H;Liu T;Zhang Z;Prince MR;Gillen K;Yan X;Song Q;Hua T;Zhao X;Zhang M;Zhao Y;Li G;Tang G;Yang G;Brittenham GM;Wang Y
R2和R2*方法在测量肝脏铁浓度(LIC)时面临的一个挑战是，纤维化、脂肪和其他肝细胞病变导致R2和R2*，并干扰LIC估计。研究肝纤维化、脂肪和其他病变对R2*LIC估计的干扰作用，并使用定量易感地形图(QSM)减少这些失真。不同浓度的Gd(Gd)、胶原(C l，模拟纤维化)和脂肪的预期水模，9例无肝病的健康对照，9例已知或疑似肝铁超载的患者，以及9例肝局灶性病变的患者。在临床1.5T和3T磁共振系统上，使用3D多回波梯度回波成像系统对模体和受试者进行成像。QSM和R2*图像由相同的梯度回波数据进行后处理。脂肪对敏感性和R2*的贡献在用于LIC估计的信号模型中进行了校正。用多项式回归分析来检验体模中敏感度、R2*与真[Gd]、[Cl]之间的关系，以及患者肝脏中敏感度与R2*之间的关系。在模体中，R2*对[Cl]、[Fate]和[Gd]有很强的非线性依赖关系，而磁化率是线性依赖的(R2>；0.98)。在患者中，R2*对肝脏病变高度敏感，包括脂肪、纤维化和肿瘤，而QSM对这些异常相对不敏感(P=0.015)。中度铁负荷时，肝脏易感性和R2*在共同的R2*范围[0,100]秒−1内不呈线性相关(P=0.35)。LIC的R2*估计容易受到脂肪、纤维化和其他病变的严重非线性干扰。对相同梯度回波的MRI数据进行QSM处理可以有效地将细胞病理的影响降到最低。
A challenge for R2 and R2* methods in measuring liver iron concentration (LIC) is that fibrosis, fat, and other hepatic cellular pathology contribute to R2 and R2* and interfere with LIC estimation. To examine the interfering effects of fibrosis, fat and other lesions on R2* LIC estimation and to use quantitative susceptibility mapping (QSM) to reduce these distortions. Prospective Water phantoms with various concentrations of gadolinium (Gd), collagen (Cl, modeling fibrosis) and fat, 9 healthy controls with no known hepatic disease, 9 patients with known or suspected hepatic iron overload, and 9 patients with focal liver lesions. The phantoms and human subjects were imaged using a 3D multi-echo gradient-echo on clinical 1.5T and 3T MRI systems. QSM and R2* images were postprocessed from the same gradient-echo data. Fat contributions to susceptibility and R2* were corrected in signal models for LIC estimation. Polynomial regression analyses were performed to examine relations among susceptibility, R2* and true [Gd] and [Cl] in phantoms, and among susceptibility and R2* in patient livers. In phantoms, R2* had a strong nonlinear dependency on [Cl], [fat] and [Gd], while susceptibility was linearly dependent (R2>0.98). In patients, R2* was highly sensitive to liver pathological changes, including fat, fibrosis and tumors, while QSM was relatively insensitive to these abnormalities (P=0.015). With moderate iron overload, liver susceptibility and R2* were not linearly correlated over a common R2* range [0, 100] sec−1 (P=0.35). R2* estimation of LIC is prone to substantial nonlinear interference from fat, fibrosis and other lesions. QSM processing of the same gradient echo MRI data can effectively minimize the effects of cellular pathology.
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