The fertility willingness and acceptability of preimplantation genetic testing in Chinese patients with autosomal dominant polycystic kidney disease
The fertility willingness and acceptability of preimplantation genetic testing in Chinese patients with autosomal dominant polycystic kidney disease
复制标题
中国常染色体显性多囊肾患者的生育意愿及植入前基因检测可接受性
DOI：
10.1186/s12882-020-01785-x
复制
发表时间：
2020-04
期刊：
影响因子：
2.3
通讯作者：
Changlin Mei
中科院分区：
文献类型：
--
作者：
Mingji Sun;Cheng Xue;Yunhui Lu;Yiyi Ma;Ting Pan;Xiaoliu Wang;Li Fan;Ji;ong Shen;Yan Hao;Danxia Zheng;Junhua Li;Mingxu Li;Yaping He;Changlin Mei
背景随着遗传学技术的发展和进步，胚胎植入前遗传学检测（Preimplantation genetic testing，PGT）使尽早阻断常染色体显性遗传性多囊肾病（autosomal dominant polycystic kidney disease，ADPKD）的遗传成为可能。方法2018年1月至2018年12月，对7家医院18-45岁ADPKD患者进行问卷调查，收集患者的基本人口学资料、生活质量、社会支持、生育意愿、对阻断ADPKD遗传基因检测的了解程度等数据。结果共调查260例ADPKD患者，其中男性137例（52.7%），女性123例（47.3%）。总体生育意愿率较低（n= 117，45.0%）。处于最佳生育年龄但尚未生育的25-34岁已婚患者比例相对较高（n= 77，67.0%）。年龄（OR：0.101，95%CI0.045 - 0.225，P <0.001）和文化程度（OR：2.134，95%CI1.162 - 3.917，P =0.014）对ADPKD患者的生育意愿有显著影响。在愿意生育的患者中，207例（79.6%）愿意选择PGT技术。在不确定是否会选择PGT技术的患者中，第一大担忧是技术安全性（49.2%）。加强ADPKD遗传知识的健康教育，降低相关技术费用，可提高生育意愿，降低PGT接受障碍。
BackgroundWith the development and progression of genetic technology, preimplantation genetic testing (PGT) has made it possible to block the inheritance of autosomal dominant polycystic kidney disease (ADPKD) as early as possible. However, we need to know the patients’ fertility intentions and their acceptance of PGT.MethodsA questionnaire survey was conducted to collect data on the basic demographic data, quality of life, social support, fertility willingness, and level of understanding of genetic testing for blocking the inheritance of ADPKD among patients aged 18–45 years in seven hospitals from January 2018 to December 2018. After verification, statistics were calculated.ResultsA total of 260 patients with ADPKD were interviewed, including 137males (52.7%) and 123 females (47.3%). The overall fertility willingness rate was low (n= 117, 45.0%). The proportion of married patients aged 25–34 years that were at the optimal reproductive age but did not yet have children was relatively high (n= 77, 67.0%). The fertility intentions of ADPKD patients were significantly influenced by age (OR: 0.101, 95% CI 0.045–0.225,P <0.001) and education level (OR: 2.134, 95% CI 1.162–3.917,P =0.014). Among patients who are willing to have children, 207 (79.6%) of them would choose PGT technology. Among those who were not sure whether they would choose PGT technology, the first major concern was technical safety (49.2%).ConclusionsThe reproductive desire of childbearing ADPKD patients in China was low. Strengthening the health education of ADPKD genetic knowledge and reducing the cost of related technologies may improve the fertility intentions and reduce the barriers to acceptance of PGT.
登录
查看更多内容
影响因子：
5.3
作者：
通讯作者：
--
DOI：
10.1016/b978-0-323-05876-6.00044-7
发表时间：
2003
期刊：
Nefrologia : publicacion oficial de la Sociedad Espanola Nefrologia
影响因子：
--
作者：
V. Torres;P. Harris
通讯作者：
V. Torres;P. Harris
影响因子：
2.9
作者：
Tang Y;Chen A;Zhu S;Yang L;Zhou J;Pan S;Shao M;Zhao L
通讯作者：
Zhao L
影响因子：
1.4
作者：
Pengju Wang;Zhuang Xiong;Huashan Yang
通讯作者：
Pengju Wang;Zhuang Xiong;Huashan Yang
影响因子：
6.1
作者：
Beaujouan, Eva;Reimondos, Anna;Sobotka, Tomas
通讯作者：
Sobotka, Tomas