Repetitive transcranial magnetic stimulation for depression after basal ganglia ischaemic stroke: protocol for a multicentre randomised double-blind placebo-controlled trial.
Repetitive transcranial magnetic stimulation for depression after basal ganglia ischaemic stroke: protocol for a multicentre randomised double-blind placebo-controlled trial.
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DOI：
10.1136/bmjopen-2017-018011
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发表时间：
2018-02-03
期刊：
影响因子：
2.9
通讯作者：
Zhao L
中科院分区：
文献类型：
--
作者：
Tang Y;Chen A;Zhu S;Yang L;Zhou J;Pan S;Shao M;Zhao L
研究表明，重复经颅磁刺激（rTMS）对抑郁症的治疗是有效的，并促进白色物质的修复。本研究旨在评估rTMS治疗基底节缺血性卒中后抑郁症的有效性，并检查这种效果是否与恢复白色物质的完整性有关。将从珠江医院、南方医院和四川八一康复医院招募66名受试者，并以1：1的比例随机分配，除常规支持治疗外，接受主动rTMS治疗或假rTMS治疗。将在治疗开始后0、2和4周收集数据。主要结果是测量24项汉密尔顿抑郁量表评分，次要结果包括弥散张量成像结果和神经心理学测试结果，包括美国国立卫生研究院卒中量表、日常生活能力量表、蒙特利尔认知评估、临床总体障碍量表、汉语失语症成套测验、社会支持再评价量表和医学应对方式问卷。本研究已获得南方医科大学珠江医院伦理委员会的批准。研究结果将通过在同行评审的期刊上发表和在国际会议上介绍的方式传播。NCT 03159351。
Studies suggest that repetitive transcranial magnetic stimulation (rTMS) is effective for the treatment of depression and promotes the repair of white matter. This study aims to assess the effectiveness of rTMS in treating depression after basal ganglia ischaemic stroke and to examine whether such effects are related to restoration of white matter integrity. Sixty-six participants will be recruited from Zhujiang Hospital, Nanfang Hospital and Sichuan Bayi Rehabilitation Hospital and randomised in a 1:1 ratio to receive active rTMS treatment or sham rTMS treatment in addition to routine supportive treatments. The data will be collected at 0, 2 and 4 weeks after the commencement of treatment. The primary outcome is the measurement of 24-item Hamilton Depression Rating Scale scores, and the secondary outcomes include diffusion tensor imaging results and the results of neuropsychological tests including the National Institutes of Health Stroke Scale, Activities of Daily Living Scale, Montreal Cognitive Assessment, Clinical Global Impressions scales, Aphasia Battery in Chinese, Social Support Revalued Scale and Medical Coping Modes Questionnaire. This study has been approved by the Ethics Committee of Zhujiang Hospital of Southern Medical University. The findings will be disseminated by publication in a peer-reviewed journal and by presentation at international conferences. NCT03159351.
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影响因子：
10.6
作者：
Sheline, YI
通讯作者：
Sheline, YI
影响因子：
10.6
作者：
Jorge, RE;Robinson, RG;Chemerinski, E
通讯作者：
Chemerinski, E
影响因子：
8.3
作者：
NARITOMI, H;SAWADA, T;TAKAMIYA, M
通讯作者：
TAKAMIYA, M
影响因子：
11.3
作者：
Nugent AC;Davis RM;Zarate CA Jr;Drevets WC
通讯作者：
Drevets WC
DOI：
10.1097/yct.0b013e3181e6317d
发表时间：
2011-03
期刊：
The journal of ECT
影响因子：
--
作者：
Kozel FA;Johnson KA;Nahas Z;Nakonezny PA;Morgan PS;Anderson BS;Kose S;Li X;Lim KO;Trivedi MH;George MS
通讯作者：
George MS