Dynamic Contrast Enhanced Magnetic Resonance Perfusion Imaging in High-Risk Smokers and Smoking-Related COPD: Correlations with Pulmonary Function Tests and Quantitative Computed Tomography
Dynamic Contrast Enhanced Magnetic Resonance Perfusion Imaging in High-Risk Smokers and Smoking-Related COPD: Correlations with Pulmonary Function Tests and Quantitative Computed Tomography
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高危吸烟者和吸烟相关慢性阻塞性肺病的动态对比增强磁共振灌注成像：与肺功能测试和定量计算机断层扫描的相关性
DOI：
10.3109/15412555.2014.948990
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发表时间：
2014-09
影响因子：
2.2
通讯作者：
Li Bing
中科院分区：
文献类型：
--
作者：
Xia Yi;Guan Yu;Fan Li;Liu Shi-Yuan;Yu Hong;Zhao Li-Ming;Li Bing
摘要本研究旨在前瞻性评价吸烟者（伴或不伴慢性阻塞性肺疾病（COPD））的动态对比增强（DCE）MR灌注成像、肺功能试验（PFT）和容积定量CT之间的相关性，并确定DCE-MR灌注成像和CT容积成像在评估吸烟者中的价值。根据ATS/ERS指南，将51名男性吸烟者分为5组：COPD风险组（n = 8）、轻度COPD组（n = 9）、中度COPD组（n = 12）、重度COPD组（n = 10）和极重度COPD组（n = 12）。从MR灌注数据中获得最大增加斜率（MSI）、正增强积分（PEI）等。计算PD与正常肺组织的信号强度比（RSI = SIPD/SInormal）。从容积CT数据获得肺总体积（TLV）、肺气肿总体积（TEV）和肺气肿指数（EI）。对于“COPD高危”患者，MR灌注成像PD阳性率高于CT平扫异常改变（p < 0.05）。所有PFT参数与SIPD或RSI之间存在中度至强正相关性（r范围为0.445 - 0.683，p ≤ 0.001）。TEV和EI与FEV 1/FVC的负相关性优于其他PFT参数（r范围-0.48--0.63，p < 0.001）。“COPD高危”与“极重度COPD”、“轻度COPD”与“极重度COPD”之间RSI和SIPD差异有统计学意义。因此，MR灌注成像可能是识别COPD早期证据的良好方法，并可能有助于COPD的分类。
Abstract The study aimed to prospectively evaluate correlations between dynamic contrast-enhanced (DCE) MR perfusion imaging, pulmonary function tests (PFT) and volume quantitative CT in smokers with or without chronic obstructive pulmonary disease (COPD) and to determine the value of DCE-MR perfusion imaging and CT volumetric imaging on the assessment of smokers. According to the ATS/ERS guidelines, 51 male smokers were categorized into five groups: At risk for COPD (n = 8), mild COPD (n = 9), moderate COPD (n = 12), severe COPD (n = 10), and very severe COPD (n = 12). Maximum slope of increase (MSI), positive enhancement integral (PEI), etc. were obtained from MR perfusion data. The signal intensity ratio (RSI) of the PDs and normal lung was calculated (RSI = SIPD/SInormal). Total lung volume (TLV), total emphysema volume (TEV) and emphysema index (EI) were obtained from volumetric CT data. For “at risk for COPD,” the positive rate of PDs on MR perfusion images was higher than that of abnormal changes on non-enhanced CT images (p < 0.05). Moderate-to-strong positive correlations were found between all the PFT parameters and SIPD, or RSI (r range 0.445∼0.683, p ≤ 0.001). TEV and EI were negatively correlated better with FEV1/FVC than other PFT parameters (r range −0.48 –−0.63, p < 0.001). There were significant differences in RSI and SIPD between “at risk for COPD” and “very severe COPD,” and between “mild COPD” and “very severe COPD”. Thus, MR perfusion imaging may be a good approach to identify early evidence of COPD and may have potential to assist in classification of COPD.
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影响因子：
4.4
作者：
Hopkins, Susan R.;Prisk, G. Kim
通讯作者：
Prisk, G. Kim
影响因子：
2.8
作者：
M. Szilasi;T. Dolinay;Z. Nemes;J. Strausz
通讯作者：
M. Szilasi;T. Dolinay;Z. Nemes;J. Strausz
影响因子：
19.7
作者：
Fink, C;Puderbach, M;Kauczor, HU
通讯作者：
Kauczor, HU
影响因子：
9.6
作者：
Zaporozhan, J;Ley, S;Kauczor, HU
通讯作者：
Kauczor, HU
影响因子：
6.7
作者：
Jang, Yu Mi;Oh, Yeon-Mok;Lee, Sang Do
通讯作者：
Lee, Sang Do