Noninvasive transcranial stimulation of rat abducens nerve by focused ultrasound.
Noninvasive transcranial stimulation of rat abducens nerve by focused ultrasound.
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DOI：
10.1016/j.ultrasmedbio.2012.04.023
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发表时间：
2012-09
影响因子：
2.9
通讯作者：
Yoo, Seung-Schik
中科院分区：
文献类型：
--
作者：
Kim, Hyungmin;Taghados, Seyed Javid;Fischer, Krisztina;Maeng, Lee-So;Park, Shinsuk;Yoo, Seung-Schik
神经功能的非药理和非手术经颅调节可能会为颅神经疾病的评估和治疗提供新的机会。这项研究调查了使用低强度经颅聚焦超声（FUS）的可能性，以选择性地刺激位于头骨底部上方的大鼠外被外展神经。在立体定向指导下，以脉冲模式下运行的FUS（350 kHz和650 kHz的频率）在脉冲模式下运行。使用0.36毫秒的音调爆发持续时间（TBD），1.5 kHz脉冲重复频率（PRF）和200毫秒的整体超声处理持续时间，在350 kHz处观察到与超声处理侧面的绑扎性眼球运动。组织学和行为监测没有表现出血液脑屏障（BBB）的破坏迹象，也没有对神经和邻近的脑组织的损害。作为一种新型的功能性神经调节方式，FUS的脉冲应用在外周神经系统疾病中具有诊断和治疗应用中的潜力。
Non-pharmacological and non-surgical transcranial modulation of the nerve function may provide new opportunities in evaluation and treatment of cranial nerve diseases. This study investigates the possibility of using low-intensity transcranial focused ultrasound (FUS) to selectively stimulate the rat abducens nerve located above the base of the skull. FUS (frequencies of 350 kHz and 650 kHz) operating in a pulsed mode was applied to the abducens nerve of Sprague-Dawley rats under stereotactic guidance. The abductive eyeball movement ipsilateral to the side of sonication was observed at 350 kHz, using the 0.36 msec tone burst duration (TBD), 1.5 kHz pulse repetition frequency (PRF), and the overall sonication duration of 200 msec. Histological and behavioral monitoring showed no signs of disruption in the blood brain barrier (BBB) as well as no damage to the nerves and adjacent brain tissue resulting from the sonication. As a novel functional neuro-modulatory modality, the pulsed application of FUS has potential in diagnostic and therapeutic applications in diseases of the peripheral nervous system.
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影响因子：
2.9
作者：
Erpelding, Todd N.;Hollman, Kyle W.;O'Donnell, Matthew
通讯作者：
O'Donnell, Matthew
影响因子：
3.3
作者：
McDannold, N;King, RL;Hynynen, K
通讯作者：
Hynynen, K
影响因子：
2.3
作者：
Clement, GT;White, PJ;Hynynen, K
通讯作者：
Hynynen, K
DOI：
10.1073/pnas.0604318103
发表时间：
2006-08-01
影响因子：
11.1
作者：
Kinoshita, Manabu;McDannold, Nathan;Hynynen, Kullervo
通讯作者：
Hynynen, Kullervo
影响因子：
2.9
作者：
Lafon, C;Zderic, V;Vaezy, S
通讯作者：
Vaezy, S