The effect of superior semicircular canal dehiscence on intracochlear sound pressures.
The effect of superior semicircular canal dehiscence on intracochlear sound pressures.
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DOI：
10.1159/000339653
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发表时间：
2012
影响因子：
1.6
通讯作者：
Nakajima HH
中科院分区：
文献类型：
--
作者：
Pisano DV;Niesten ME;Merchant SN;Nakajima HH
半规管裂开（SCD）是内耳骨性壁的一种病理性开口，可导致传导性听力损失。听力损失在患者之间是可变的，并且精确的机制和可变性的来源尚未完全理解。同时测量前庭阶（SV）和鼓阶（ST）中的基础耳蜗内声压使得能够量化耳蜗分区上的压差，该压差是激励耳蜗分区的刺激。我们在尸体准备中使用颅内声压测量来研究SCD大小的影响。同时测量了不同尺寸SCD的SV和ST的声诱导压力以及镫骨速度和耳道压力，然后进行SCD修补。我们的研究结果表明，在低频率（<600 Hz），SCD降低SV和ST的压力，以及压差，这些影响变得更加明显，开裂的大小增加。在100 Hz附近，SV对于0.5 mm开裂降低约10 dB，对于2 mm开裂降低约20 dB，而ST对于0.5 mm开裂降低约8 dB，对于2 mm开裂降低约18 dB。在100 Hz下，0.5 mm开裂的压差降低约10 dB，2 mm开裂的压差降低约20 dB。在某些耳朵中，对于1 kHz以上的频率，最小的针尖裂开对压差的影响（降低10 dB）大于较大的裂开（降低小于10 dB），这表明在该频率范围内听力损失较大。SCD引起的这些影响可通过修补裂开处逆转。我们还表明，在某些情况下，如SCD，镫骨速度是不相关的耳朵如何可以跨越耳蜗分区的声音，因为它是不直接相关的压差，强调某些病理不能完全评估的测量，如镫骨速度。
Semicircular canal dehiscence (SCD) is a pathological opening in the bony wall of the inner ear that can result in conductive hearing loss. The hearing loss is variable across patients, and the precise mechanism and source of variability are not fully understood. Simultaneous measurements of basal intracochlear sound pressures in scala vestibuli (SV) and scala tympani (ST) enable quantification of the differential pressure across the cochlear partition, the stimulus that excites the cochlear partition. We used intracochlear sound pressure measurements in cadaveric preparations to study the effects of SCD size. Sound-induced pressures in SV and ST, as well as stapes velocity and ear-canal pressure were measured simultaneously for various sizes of SCD followed by SCD patching. Our results showed that at low frequencies (<600 Hz), SCD decreased the pressure in both SV and ST, as well as differential pressure, and these effects became more pronounced as dehiscence size was increased. Near 100 Hz, SV decreased about 10 dB for a 0.5 mm dehiscence and 20 dB for a 2 mm dehiscence, while ST decreased about 8 dB for a 0.5 mm dehiscence and 18 dB for a 2mm dehiscence. Differential pressure decreased about 10 dB for a 0.5 mm dehiscence and about 20 dB for a 2 mm dehiscense at 100 Hz. In some ears, for frequencies above 1 kHz, the smallest pinpoint dehiscence had bigger effects on the differential pressure (10 dB decrease) than larger dehiscenses (less than 10 dB decrease), suggesting larger hearing losses in this frequency range. These effects due to SCD were reversible by patching the dehiscence. We also showed that under certain circumstances such as SCD, stapes velocity is not related to how the ear can transduce sound across the cochlear partition because it is not directly related to the differential pressure, emphasizing that certain pathologies cannot be fully assessed by measurements such as stapes velocity.
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影响因子：
2.6
作者：
Martin, Christian;Chahine, Pierre;Pouget, Jean Francois
通讯作者：
Pouget, Jean Francois
影响因子：
2.1
作者：
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影响因子：
2.4
作者：
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通讯作者：
Olson, ES
DOI：
10.1007/s10162-008-0150-y
发表时间：
2009-03-01
影响因子：
2.4
作者：
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通讯作者：
Rosowski, John J.
影响因子：
2.1
作者：
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通讯作者：
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