Prussian Blue Nanoparticles as a Versatile Photothermal Tool.

Prussian Blue Nanoparticles as a Versatile Photothermal Tool.
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DOI:
10.3390/molecules23061414
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发表时间:
2018-06-11
期刊:
Molecules (Basel, Switzerland)
影响因子:
--
通讯作者:
Pallavicini P
Pallavicini P
中科院分区:
其他
文献类型:
--
作者:
Dacarro G;Taglietti A;Pallavicini P

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普鲁士蓝(PB)是一种配位聚合物,自世纪初开始研究,历史上被称为颜料。PB可以通过简单的合成以胶体形式制备。它在~700 nm处有很强的电荷转移吸收,在近红外范围内有很大的拖尾。该波段的辐射导致热弛豫,并且可以通过在所谓的生物透明近红外窗口中辐射来利用该波段的辐射来产生局部高热。PB纳米颗粒是完全生物相容的(PB已被FDA批准)和可生物降解的,这使它们成为体内使用的理想候选物。在过去的几十年里,基于PB纳米颗粒的成像、药物递送和吸收特性的论文已经出现并进行了综述,最近的兴趣随着PB纳米颗粒在生物医学应用中作为光热剂的使用而蓬勃发展。本文综述了PB纳米粒子的合成和光学特性与其光热用途的关系,并介绍了PB纳米粒子作为光热剂的最新技术水平,以及与诊断技术的结合。
Prussian blue (PB) is a coordination polymer studied since the early 18th century, historically known as a pigment. PB can be prepared in colloidal form with a straightforward synthesis. It has a strong charge-transfer absorption centered at ~700 nm, with a large tail in the Near-IR range. Irradiation of this band results in thermal relaxation and can be exploited to generate a local hyperthermia by irradiating in the so-called bio-transparent Near-IR window. PB nanoparticles are fully biocompatible (PB has already been approved by FDA) and biodegradable, this making them ideal candidates for in vivo use. While papers based on the imaging, drug-delivery and absorbing properties of PB nanoparticles have appeared and have been reviewed in the past decades, a very recent interest is flourishing with the use of PB nanoparticles as photothermal agents in biomedical applications. This review summarizes the syntheses and the optical features of PB nanoparticles in relation to their photothermal use and describes the state of the art of PB nanoparticles as photothermal agents, also in combination with diagnostic techniques.
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