SCHISTOX: An individual based model for the epidemiology and control of schistosomiasis.

SCHISTOX: An individual based model for the epidemiology and control of schistosomiasis.
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DOI:
10.1016/j.idm.2021.01.010
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发表时间:
2021
影响因子:
8.8
通讯作者:
Toor J
Toor J
中科院分区:
医学4区
文献类型:
--
作者:
Graham M;Ayabina D;Lucas TC;Collyer BS;Medley GF;Hollingsworth TD;Toor J

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一个基于随机个体的模型SCHISTOX已经发展起来,用于研究血吸虫传播动力学和大规模给药控制的影响。可以研究的更多新方面包括个体水平的依从性和获得治疗的机会、多个社区、人类性行为人口动态以及潜在疫苗的实施。许多模型参数是在以前的研究中估计的,并已显示出在不同社区之间存在差异,例如控制感染年龄分布的特定年龄接触率。然而,不确定性仍然存在,因为某些参数值的范围很大,少数参数值仍然相对未知。我们通过用已公布的参数值对模型进行参数化来分析模型的动力学。我们还将以开放源码的GitHub存储库的形式讨论SCHISTOX的开发。下一个关键开发阶段涉及通过校准流行病学数据来验证该模型。
A stochastic individual based model, SCHISTOX, has been developed for the study of schistosome transmission dynamics and the impact of control by mass drug administration. More novel aspects that can be investigated include individual level adherence and access to treatment, multiple communities, human sex population dynamics, and implementation of a potential vaccine. Many of the model parameters have been estimated within previous studies and have been shown to vary between communities, such as the age-specific contact rates governing the age profiles of infection. However, uncertainty remains as there are wide ranges for certain parameter values and a few remain relatively unknown. We analyse the model dynamics by parameterizing it with published parameter values. We also discuss the development of SCHISTOX in the form of a publicly available open-source GitHub repository. The next key development stage involves validating the model by calibrating to epidemiological data.
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