Heartland virus infection in hamsters deficient in type I interferon signaling: Protracted disease course ameliorated by favipiravir.
Heartland virus infection in hamsters deficient in type I interferon signaling: Protracted disease course ameliorated by favipiravir.
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DOI：
10.1016/j.virol.2017.08.004
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发表时间：
2017-11
期刊：
影响因子：
3.7
通讯作者：
Gowen BB
中科院分区：
文献类型：
--
作者：
Westover JB;Rigas JD;Van Wettere AJ;Li R;Hickerson BT;Jung KH;Miao J;Reynolds ES;Conrad BL;Nielson S;Furuta Y;Thangamani S;Wang Z;Gowen BB
心脏地带病毒（HRTV）是一种新出现的蜱传病毒（布尼亚病毒科，白蛉病毒），在美国中部和中东部几个州造成了人间散发病例。需要HRTV疾病的动物模型来深入了解病毒的发病机制和推进抗病毒药物的开发。STAT2功能缺乏的仓鼠HRTV攻击后出现临床疾病，强调了I型干扰素诱导的抗病毒反应的重要作用。然而，大多数受感染动物的康复表明，控制感染和限制疾病的其他机制提供了实质性的保护。STAT2敲除仓鼠HRTV感染最突出的疾病体征是体重急剧减轻，临床实验室和组织病理学显示脾脏、淋巴结、肝脏和肺部出现急性炎症。最后，我们表明，仓鼠HRTV疾病可以通过使用favipiravir来预防，favipiravir是一种很有前途的用于治疗流感的广谱抗病毒药物。
Heartland virus (HRTV) is an emerging tick-borne virus (Bunyaviridae, Phlebovirus) that has caused sporadic cases of human disease in several central and mid-eastern states of America. Animal models of HRTV disease are needed to gain insights into viral pathogenesis and advancing antiviral drug development. Presence of clinical disease following HRTV challenge in hamsters deficient in STAT2 function underscores the important role played by type I interferon-induced antiviral responses. However, the recovery of most of the infected animals suggests that other mechanisms to control infection and limit disease offer substantial protection. The most prominent disease sign with HRTV infection in STAT2 knockout hamsters was dramatic weight loss with clinical laboratory and histopathology demonstrating acute inflammation in the spleen, lymph node, liver and lung. Finally, we show that HRTV disease in hamsters can be prevented by the use of favipiravir, a promising broad-spectrum antiviral in clinical development for the treatment of influenza.
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影响因子：
11.8
作者：
Riemersma KK;Komar N
通讯作者：
Komar N
影响因子：
7.6
作者：
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DOI：
10.3390/v8080220
发表时间：
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期刊：
Viruses
影响因子：
--
作者：
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通讯作者：
Thangamani S
影响因子：
3.8
作者：
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影响因子：
3.3
作者：
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通讯作者：
Branlt, Aaron C.