Early Functional and Cognitive Declines Measured by Auditory-Evoked Cortical Potentials in Mice With Alzheimer's Disease.
Early Functional and Cognitive Declines Measured by Auditory-Evoked Cortical Potentials in Mice With Alzheimer's Disease.
复制标题
DOI：
10.3389/fnagi.2021.710317
复制
发表时间：
2021
影响因子：
4.8
通讯作者：
Zhao HB
中科院分区：
文献类型：
--
作者：
Mei L;Liu LM;Chen K;Zhao HB
阿尔茨海默病（AD）的特征在于进行性记忆丧失和认知能力下降。然而，AD相关的功能和认知变化的评估仍然是一个很大的挑战。听觉诱发皮层电位（AECP）是一种事件相关电位，不仅反映听觉皮层（AC）的神经活动，而且反映大脑的认知活动。本研究采用与听性脑干反应（ABR）记录相同电极设置的皮下针电极，记录了正常衰老CBA/CaJ小鼠和APP/PS1 AD小鼠的AECP。小鼠AECP通常呈现三个阳性峰，P1、P2和P3，以及三个相应的负峰，即，N1、N2和N3。在正常衰老CBA小鼠中，早期感觉峰P1、N1和P2随着年龄的增加而减少，而后期认知峰N2、P3和N3随着年龄的增加而增加或没有变化。此外，P1峰的潜伏期随着年龄的增加而增加，尽管后期峰的潜伏期随着年龄的增加而显著减少。在AD小鼠中，P1峰在幼年时与野生型（WT）同窝仔相比显著降低，继续AD表型呈现。特别是，晚认知峰P3在3个月后减弱，不同于正常的老化效应。而AD小鼠AECP峰的延长一般不随增龄而明显延迟或改变。最后，与AECP变化一致，早在2个月大的AD小鼠中，AC处的淀粉样前体蛋白（APP）的积累是可见的。这些数据表明，AECP可以作为检测AD和AD相关痴呆（ADRD）的早期，非侵入性和客观的生物标志物。
Alzheimer’s disease (AD) is characterized by a progressive loss of memory and cognitive decline. However, the assessment of AD-associated functional and cognitive changes is still a big challenge. Auditory-evoked cortical potential (AECP) is an event-related potential reflecting not only neural activation in the auditory cortex (AC) but also cognitive activity in the brain. In this study, we used the subdermal needle electrodes with the same electrode setting as the auditory brainstem response (ABR) recording and recorded AECP in normal aging CBA/CaJ mice and APP/PS1 AD mice. AECP in mice usually appeared as three positive peaks, i.e., P1, P2, and P3, and three corresponding negative peaks, i.e., N1, N2, and N3. In normal aging CBA mice, the early sensory peaks P1, N1, and P2 were reduced as age increased, whereas the later cognitive peaks N2, P3, and N3 were increased or had no changes with aging. Moreover, the latency of the P1 peak was increased as age increased, although the latencies of later peaks had a significant reduction with aging. In AD mice, peak P1 was significantly reduced in comparison with wild-type (WT) littermates at young ages, proceeding AD phenotype presentation. In particular, the later cognitive peak P3 was diminished after 3 months old, different from the normal aging effect. However, the latencies of AECP peaks in AD mice generally had no significant delay or changes with aging. Finally, consistent with AECP changes, the accumulation of amyloid precursor protein (APP) at the AC was visible in AD mice as early as 2 months old. These data suggest that AECP could serve as an early, non-invasive, and objective biomarker for detecting AD and AD-related dementia (ADRD).
登录
查看更多内容
影响因子：
13.1
作者：
Swords, Gabriel M.;Nguyen, Lydia T.;Mudar, Raksha A.;Llano, Daniel A.
通讯作者：
Llano, Daniel A.
影响因子：
--
作者：
Sur S;Sinha VK
通讯作者：
Sinha VK
影响因子：
2.5
作者：
Liu, Yang;Fang, Shu;Zhao, Hong-Bo
通讯作者：
Zhao, Hong-Bo
影响因子：
3.3
作者：
Wang, J;Ikonen, S;Tanila, H
通讯作者：
Tanila, H
影响因子：
9.9
作者：
Golob, E. J.;Ringman, J. M.;Starr, A.
通讯作者：
Starr, A.