Auditory system dysfunction in Alzheimer disease and its prodromal states: A review.
Auditory system dysfunction in Alzheimer disease and its prodromal states: A review.
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DOI：
10.1016/j.arr.2018.04.001
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发表时间：
2018-07
影响因子：
13.1
通讯作者：
Llano, Daniel A.
中科院分区：
文献类型：
--
作者：
Swords, Gabriel M.;Nguyen, Lydia T.;Mudar, Raksha A.;Llano, Daniel A.
最近的研究结果表明，外周和中枢听觉系统功能障碍发生在阿尔茨海默病（AD）的前驱期，因此可能是疾病的早期指标。此外，听觉功能丧失本身会导致AD患者及其护理人员的沟通困难、社交孤立和生活质量低下。对早期AD的听觉功能障碍有更深入的了解，可能有助于阐明疾病进展的机制，并具有诊断和治疗的重要性。在此，我们回顾了AD及其前驱期听力能力的文献，通过纯音测听，双耳分听任务和诱发反应电位等方法进行了研究。我们建议在高危人群中筛查外周和中枢听觉功能障碍是识别早期AD病理的低成本和有效手段，并为提高AD患者生活质量的治疗干预提供了切入点。
Recent findings suggest that both peripheral and central auditory system dysfunction occur in the prodromal stages of Alzheimer Disease (AD), and therefore may represent early indicators of the disease. In addition, loss of auditory function itself leads to communication difficulties, social isolation and poor quality of life for both patients with AD and their caregivers. Developing a greater understanding of auditory dysfunction in early AD may shed light on the mechanisms of disease progression and carry diagnostic and therapeutic importance. Herein, we review the literature on hearing abilities in AD and its prodromal stages investigated through methods such as pure-tone audiometry, dichotic listening tasks, and evoked response potentials. We propose that screening for peripheral and central auditory dysfunction in at-risk populations is a low-cost and effective means to identify early AD pathology and provides an entry point for therapeutic interventions that enhance the quality of life of AD patients.
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DOI：
10.1016/0013-4694(96)95049-x
发表时间：
1996-09-01
期刊：
ELECTROENCEPHALOGRAPHY AND CLINICAL NEUROPHYSIOLOGY
影响因子：
--
作者：
Ford, JM;Woodward, SH;Roth, WT
通讯作者：
Roth, WT
DOI：
10.1044/2016_jslhr-h-16-0066
发表时间：
2017-05-01
影响因子：
2.6
作者：
Edwards, Jerri D.;Lister, Jennifer J.;Bush, Aryn L. Harrison
通讯作者：
Bush, Aryn L. Harrison
影响因子：
3
作者：
Bidelman, Gavin M.
通讯作者：
Bidelman, Gavin M.
影响因子：
4.7
作者：
Golob, EJ;Starr, A
通讯作者：
Starr, A
DOI：
10.1016/s0006-291x(84)80190-4
发表时间：
1984-01-01
影响因子：
3.1
作者：
GLENNER, GG;WONG, CW
通讯作者：
WONG, CW