Measuring Clinical Treatment Response in Myasthenia Gravis.
Measuring Clinical Treatment Response in Myasthenia Gravis.
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DOI：
10.1016/j.ncl.2018.01.006
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发表时间：
2018-05
影响因子：
2.4
通讯作者：
Barohn RJ
中科院分区：
文献类型：
--
作者：
Barnett C;Herbelin L;Dimachkie MM;Barohn RJ
健康有几个方面是可以衡量的，这些方面代表了疾病的不同方面，从病理生理学(如抗体效价)到症状和体征，再到对个人的影响及其与社会的关系。1由于不同的结果衡量标准针对疾病进程的不同方面，因此必须了解某一特定工具衡量的是什么，以及它是为什么目的开发的，以及在哪个人群中进行测试。了解疾病这些不同方面的一种方法是通过世界卫生组织出版的《国际功能、残疾和健康分类》2。ICF确定了疾病或伤害对个人产生影响的三种主要方式：身体功能或结构的损害，基本上是体征和症状；活动限制，即疾病及其症状对日常生活活动的影响；参与限制，即对患者的社交活动的影响，如寻找工作或照顾家人。此外，疾病的这些方面还受到个人和环境因素的影响(如社会支持、文化因素和可获得性)。根据ICF的说法，残疾是症状、活动和参与限制与个人和环境因素之间的相互作用。2与健康相关的生活质量超越了残疾的概念，从定义上讲，它是一个主观和多维的概念，包括身体功能、精神或心理健康、职业状况和社会互动。3身体功能/结构的损害被认为受社会和环境因素的影响较小，因此通常被认为更直接地反映疾病的严重程度。这就是为什么大多数旨在量化疾病严重程度的结果衡量标准都能捕捉到体征和症状，而衡量标准则侧重于
There are several aspects of health that can be measured, and these represent different aspects of the disease, from the pathophysiology (eg, antibody titers), to the symptoms and signs, to the effect on the individual and their relation to society. 1 Because different outcome measures are aimed at different aspects of the disease process, it is fundamental to understand what a given tool measures, as well as for which purpose it was developed and in which population it was tested. One way to understand these different aspects of the disease is through the International Classification of Functioning, Disability and Health (ICF), 2 published by the World Health Organization. The ICF identifies 3 major ways in which a disease or injury affects in individual: impairments of body function or structures, which are basically the signs and symptoms; activity limitations, which are the effects of the disease and its symptoms on activities of daily life; and participation limitations, which are the effects on a patient’s social interactions, such as looking for work or caring for their family. Additionally, these aspects of the disease are also affected by personal and environmental factors (eg, social support, cultural factors, and accessibility). Disability is—according to the ICF—the interaction between symptoms, activities, and participation restrictions and personal and environmental factors. 2 Health-related quality of life (HRQoL) goes beyond the concept of disability and it is, by definition, a subjective and multidimensional concept, including physical functioning, mental or psychological well-being, occupational status, and social interactions. 3 The impairments of body functions/structures are thought to be less affected by social and environmental factors and, therefore, are typically considered to reflect more directly disease severity. This factor is why most outcome measures aimed at quantifying disease severity capture the signs and symptoms, whereas measures focused on
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DOI：
10.1111/j.1749-6632.2012.06771.x
发表时间：
2012-01-01
期刊：
MYASTHENIA GRAVIS AND RELATED DISORDERS I
影响因子：
--
作者：
Baggi, Fulvio;Mantegazza, Renato;Sanders, Donald
通讯作者：
Sanders, Donald
影响因子：
3.4
作者：
Farrugia, Maria E.;Harle, Heather D.;Burns, Ted M.
通讯作者：
Burns, Ted M.
影响因子：
11
作者：
Barnett, Carolina;Wilson, Graham;Bril, Vera
通讯作者：
Bril, Vera
DOI：
10.1111/j.1749-6632.1998.tb11015.x
发表时间：
1998-01-01
期刊：
MYASTHENIA GRAVIS AND RELATED DISEASES
影响因子：
--
作者：
Barohn, RJ;McIntire, D;Bryan, WW
通讯作者：
Bryan, WW
影响因子：
9.9
作者：
Burns, Ted M.;Conaway, Mark;Sanders, Donald B.
通讯作者：
Sanders, Donald B.