The relationship between cognitive clusters and telomere length in bipolar-schizophrenia spectrum disorders
The relationship between cognitive clusters and telomere length in bipolar-schizophrenia spectrum disorders
复制标题
双相精神分裂症谱系障碍中认知簇与端粒长度的关系
作者：
C. Gurvich;N. Thomas;Abdul;T. V. Van Rheenen;Elizabeth H. X. Thomas;E. Tan;E. Neill;S. Carruthers;P. Sumner;M. Romano‐Silva;K. Bozaoglu;J. Kulkarni;S. Rossell
摘要背景精神分裂症和双相情感障碍是与认知缺陷相关的复杂精神疾病。在这两种疾病中存在相当大的认知异质性。将精神分裂症和双相情感障碍患者根据其认知特征分组的研究越来越多地表明，相对于健康对照组，存在严重受损的亚组和相对完整的亚组。有新的证据表明，端粒缩短，细胞衰老的标志，可能与认知障碍。本研究的目的是探讨双相精神分裂症谱系障碍的认知亚群与端粒长度之间的关系，并与健康对照样本进行比较。方法参与者包括诊断为双相情感障碍、精神分裂症或分裂情感障碍的转诊断组（n = 73）和健康对照组（n = 113）。基于当前认知功能（MATRICS共识认知成套测验评分），使用K均值聚类分析确定跨诊断患者组内的认知聚类。使用从全血中提取的基因组DNA定量PCR测定端粒长度。然后将出现的簇与健康对照组的端粒长度进行比较。结果在患者组中出现了两个聚类，被认为反映了相对完整的认知组和认知受损的亚组。与健康对照组相比，严重认知障碍亚组的端粒长度明显较短。结论本研究重复了先前跨诊断认知亚组的发现，并将较短的端粒长度与严重受损的认知亚组联系起来。这些发现支持了将精神疾病中的认知障碍与端粒长度所指示的加速细胞衰老相关联的新兴文献。
Abstract Background Schizophrenia and bipolar disorder are complex mental illnesses that are associated with cognitive deficits. There is considerable cognitive heterogeneity that exists within both disorders. Studies that cluster schizophrenia and bipolar patients into subgroups based on their cognitive profile increasingly demonstrate that, relative to healthy controls, there is a severely compromised subgroup and a relatively intact subgroup. There is emerging evidence that telomere shortening, a marker of cellular senescence, may be associated with cognitive impairments. The aim of this study was to explore the relationship between cognitive subgroups in bipolar-schizophrenia spectrum disorders and telomere length against a healthy control sample. Methods Participants included a transdiagnostic group diagnosed with bipolar, schizophrenia or schizoaffective disorder (n = 73) and healthy controls (n = 113). Cognitive clusters within the transdiagnostic patient group, were determined using K-means cluster analysis based on current cognitive functioning (MATRICS Consensus Cognitive Battery scores). Telomere length was determined using quantitative PCRs genomic DNA extracted from whole blood. Emergent clusters were then compared to the healthy control group on telomere length. Results Two clusters emerged within the patient group that were deemed to reflect a relatively intact cognitive group and a cognitively impaired subgroup. Telomere length was significantly shorter in the severely impaired cognitive subgroup compared to the healthy control group. Conclusions This study replicates previous findings of transdiagnostic cognitive subgroups and associates shorter telomere length with the severely impaired cognitive subgroup. These findings support emerging literature associating cognitive impairments in psychiatric disorders to accelerated cellular aging as indexed by telomere length.
影响因子：
25.8
作者：
Fett, Anne-Kathrin J.;Velthorst, Eva;Kotov, Roman
通讯作者：
Kotov, Roman
影响因子：
14.9
作者：
Cawthon, RM
通讯作者：
Cawthon, RM
DOI：
10.1073/pnas.85.18.6622
发表时间：
1988-09-01
影响因子：
11.1
作者：
MOYZIS, RK;BUCKINGHAM, JM;WU, JR
通讯作者：
WU, JR