A systemic pan-cancer analysis of MPZL3 as a potential prognostic biomarker and its correlation with immune infiltration and drug sensitivity in breast cancer.
A systemic pan-cancer analysis of MPZL3 as a potential prognostic biomarker and its correlation with immune infiltration and drug sensitivity in breast cancer.
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DOI：
10.3389/fonc.2022.901728
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发表时间：
2022
影响因子：
4.7
通讯作者：
Shen, Kunwei
中科院分区：
文献类型：
--
作者：
Huang, Renhong;Li, Liangqiang;Wang, Zheng;Shen, Kunwei
本研究旨在分析髓鞘蛋白零样蛋白3(MPZL3)这一单膜糖蛋白在人类肿瘤预后、肿瘤免疫浸润和药物敏感性中的作用。关于MPZL3的数据从TCGA、GTEx、CellMiner、CCLE、Timer、GSEA和USCS Xena数据库中提取。用R语言软件分析MPZL3的表达差异、生存结局、DNA甲基化、肿瘤突变负荷(TMB)、微卫星不稳定性(MSI)、错配修复(MMR)、肿瘤微环境(TME)、免疫细胞浸润和药物敏感性。应用细胞增殖和药敏试验分析MPZL3在乳腺癌中的生物学作用和药敏情况。MPZL3在大多数癌症类型中高表达，并与几种癌症的不良生存结局相关。TMB、MSI、MMR、DNA甲基化和RNA修饰在介导肿瘤中MPZL3异常表达中起重要作用，MPZL3与CD8+T细胞和CD4+T细胞免疫浸润密切相关。MPML3mRNA水平与蛋白质分泌、Notch信号通路和血红素代谢有关。此外，药物敏感性分析和验证还表明，MPZL3的表达影响了针对EGFR、ABL、FGFR等药物的敏感性。此外，MPZL3的过表达还促进了不同亚型乳腺癌的增殖和药物敏感性。这项研究对泛癌基因MPZL3在包括乳腺癌在内的不同肿瘤中的致癌作用提供了全面的分析和理解。MPZL3有望成为判断乳腺癌预后的生物标志物和治疗靶点。
This study aimed to analyze the role of myelin protein zero-like 3 (MPZL3), a single membrane glycoprotein, in prognosis, tumor immune infiltration, and drug susceptibility in human cancers. Data regarding MPZL3 were extracted from the TCGA, GTEx, CellMiner, CCLE, TIMER, GSEA, and USCS Xena databases. The expression difference, survival outcomes, DNA methylation, tumor mutation burden (TMB), microsatellite instability (MSI), mismatch repair (MMR), tumor microenvironment (TME), immune cell infiltration, and drug sensitivity of MPZL3 were analyzed by R language software. Cell proliferation and drug sensitivity tests were applied to analyze the biological role of MPZL3 and drug sensitivities in breast cancer. MPZL3 was highly expressed in most cancer types and correlated with unfavorable survival outcomes in several cancers. TMB, MSI, MMR, DNA methylation, and RNA modification played a significant role in mediating MPZL3 dysregulation in cancers, and MPZL3 was closely linked to CD8+ T cells and CD4+ T immune infiltration. The MPML3 mRNA level was associated with protein secretion, the Notch signaling pathway, and heme metabolism. In addition, drug sensitivity analysis and validation also indicated that MPZL3 expression influenced the sensitivity of therapeutics targeting EGFR, ABL, FGFR, etc. Additionally, MPZL3 overexpression contributed to proliferation and drug sensitivity in different subtypes of breast cancer. This study provides a comprehensive analysis and understanding of the oncogenic roles of the pan-cancer gene MPZL3 across different tumors, including breast cancer. MPZL3 could be a potential prognostic biomarker and therapeutic target for breast cancer.
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影响因子：
29.4
作者：
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通讯作者：
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作者：
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