UV radiation and the skin.
UV radiation and the skin.
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DOI：
10.3390/ijms140612222
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发表时间：
2013-06-07
影响因子：
5.6
通讯作者：
Scott T
中科院分区：
文献类型：
--
作者：
D'Orazio J;Jarrett S;Amaro-Ortiz A;Scott T
紫外线辐射(UV)被归类为“完全致癌物”，因为它既是诱变剂，又是非特异性损害剂，既具有肿瘤启动剂的特性，又具有肿瘤促进剂的特性。在环境丰富的情况下，紫外线是皮肤癌和许多其他环境影响的皮肤病最重要的可改变的风险因素。然而，紫外线也通过调节皮肤中维生素D和内啡肽的自然合成而有益于人类健康，因此紫外线对人类健康具有复杂而复杂的影响。尽管如此，过度暴露在紫外线下会带来严重的健康风险，包括萎缩、色素变化、皱纹和恶性肿瘤。紫外线在流行病学和分子水平上与三种最常见的皮肤癌--基底细胞癌、鳞状细胞癌和恶性黑色素瘤--有关，这些癌症每年总共影响100多万美国人。遗传因素也影响紫外线介导的皮肤病的风险。黑素皮质素1受体(MC1R)基因的多态尤其与皮肤白皙、紫外线敏感性和癌症风险增加有关。我们有兴趣在详细了解紫外线照射后发生的分子事件的基础上开发紫外线防护方法，特别是关注表皮黑化和MC1R在基因组维护中的作用。
UV radiation (UV) is classified as a “complete carcinogen” because it is both a mutagen and a non-specific damaging agent and has properties of both a tumor initiator and a tumor promoter. In environmental abundance, UV is the most important modifiable risk factor for skin cancer and many other environmentally-influenced skin disorders. However, UV also benefits human health by mediating natural synthesis of vitamin D and endorphins in the skin, therefore UV has complex and mixed effects on human health. Nonetheless, excessive exposure to UV carries profound health risks, including atrophy, pigmentary changes, wrinkling and malignancy. UV is epidemiologically and molecularly linked to the three most common types of skin cancer, basal cell carcinoma, squamous cell carcinoma and malignant melanoma, which together affect more than a million Americans annually. Genetic factors also influence risk of UV-mediated skin disease. Polymorphisms of the melanocortin 1 receptor (MC1R) gene, in particular, correlate with fairness of skin, UV sensitivity, and enhanced cancer risk. We are interested in developing UV-protective approaches based on a detailed understanding of molecular events that occur after UV exposure, focusing particularly on epidermal melanization and the role of the MC1R in genome maintenance.
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影响因子：
--
作者：
Choi, Kelvin;Lazovich, DeAnn;Jackson, Jody
通讯作者：
Jackson, Jody
影响因子：
6.5
作者：
BENEDETTO, JP;ORTONNE, JP;THIVOLET, J
通讯作者：
THIVOLET, J
DOI：
10.1038/jidsymp.2009.10
发表时间：
2009-08
影响因子：
--
作者：
Coelho, Sergio G.;Choi, Wonseon;Brenner, Michaela;Miyamura, Yoshinori;Yamaguchi, Yuji;Wolber, Rainer;Smuda, Christoph;Batzer, Jan;Kolbe, Ludger;Ito, Shosuke;Wakamatsu, Kazumasa;Zmudzka, Barbara Z.;Beer, Janusz Z.;Miller, Sharon A.;Hearing, Vincent J.
通讯作者：
Hearing, Vincent J.
影响因子：
6.7
作者：
BOYLE, P;MAISONNEUVE, P;DORE, JF
通讯作者：
DORE, JF
影响因子：
3.3
作者：
COSTANTINI, C;DISCHIA, M;PROTA, G
通讯作者：
PROTA, G