The role of adhesion molecules, chemotactic factors, and cytokines in inflammatory and neoplastic skin disease--1990 update.
The role of adhesion molecules, chemotactic factors, and cytokines in inflammatory and neoplastic skin disease--1990 update.
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粘附分子、趋化因子和细胞因子在炎症和肿瘤性皮肤病中的作用 - 1990 年更新。
DOI：
10.1111/1523-1747.ep12876134
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发表时间：
1990
期刊：
影响因子：
--
通讯作者：
Barker,JN
中科院分区：
文献类型：
--
作者：
Nickoloff,BJ;Griffiths,CE;Barker,JN
1986年，发现培养的人角质形成细胞在用γ干扰素处理时吸引并结合T淋巴细胞和单核细胞。现在我们对皮肤中炎性细胞的运输有了更多的了解，具体的分子细节涉及各种细胞因子、趋化因子和粘附分子。一个关键因素是表达LFA-1的T细胞在体内运动进入表皮，随后通过细胞间粘附分子-1（ICAM-1）的表面表达与角质形成细胞结合。这种相互作用代表了一种常见的免疫途径，已在各种不同的皮肤疾病中得到鉴定。本文综述了在这一领域的进展，在过去几年中迅速增长的一个概要，并增加了最近的结果处理协调调节在基因转录水平的角质形成细胞趋化因子的生产和粘附分子的表达。此外，表皮角质形成细胞似乎在皮肤中起着突出的作用，作为转导元件，将外源施加的低分子量化学刺激物如佛波酯和漆酚（毒葛提取物中的活性成分）转化为内源性免疫调节蛋白的产生。这些角化细胞衍生的分子然后可以影响免疫细胞和内皮细胞以进一步放大炎症反应。角质形成细胞衍生的分子，如IL-8和ICAM-1，影响T细胞的趋化性和粘附的鉴定，增加了大量的证据支持角质形成细胞在皮肤免疫稳态中的积极参与作用。最后，我们强调了这些免疫调节分子在两种恶性皮肤疾病（皮肤T细胞淋巴瘤和基底细胞癌）中的重要性，并试图将这些新发现整合到两种炎症性皮肤病（漆树皮炎和银屑病）的新病理生理模型中。
In 1986 it was discovered that cultured human keratinocytes, when treated with gamma interferon, attract and bind T lymphocytes and monocytes. More is now known about trafficking of inflammatory cells in the skin, with specific molecular details involving various cytokines, chemotactic factors, and adhesion molecules. One key element is the in vivo movement of T cells that express LFA-1 into the epidermis, and their subsequent binding to keratinocytes via the surface expression of intercellular adhesion molecule-1 (ICAM-1). This interaction represents a common immunologic pathway, which has been identified in a wide variety of different skin diseases. This review provides a synopsis of advances in this field, which have grown rapidly during the past few years, and adds recent results dealing with coordinate regulation at the gene-transcriptional level of keratinocyte chemotactic factor production and adhesion molecule expression. Moreover, epidermal keratinocytes appear to play a pre-eminent role in the skin, serving as transducing elements converting exogenously applied low-molecular-weight chemical stimuli such as phorbol ester and urushiol (the active ingredient in poison ivy extracts) into the production of endogenously derived immunoregulatory proteins. These keratinocyte-derived molecules may then influence immunocytes and endothelial cells to further amplify the inflammatory response. The identification of keratinocyte-derived molecules such as IL-8 and ICAM-1, which influence the chemotaxis and adherence of T cells, adds substantial evidence supporting an active participatory role for keratinocytes in cutaneous immunohomeostasis. Finally, we highlight the importance of these immunoregulatory molecules in two malignant cutaneous disorders (cutaneous T-cell lymphoma and basal-cell carcinoma) and attempt to integrate these new findings into novel pathophysiologic models for two inflammatory dermatoses (rhus dermatitis and psoriasis).
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影响因子：
--
作者：
G. Fierlbeck;G. Rassner;C. Müller
通讯作者：
G. Fierlbeck;G. Rassner;C. Müller
淋巴细胞与银屑病真皮内皮的粘附是由组织特异性受体/配体相互作用介导的。
DOI：
10.1111/1523-1747.ep12476441
发表时间：
1988
期刊：
The Journal of investigative dermatology
影响因子：
--
作者：
Sackstein,R;Falanga,V;Streilein,JW;Chin,YH
通讯作者：
Chin,YH
受累和未受累银屑病皮肤中的高内皮小静脉：细胞毒性 T 淋巴细胞上归巢受体的识别
影响因子：
10.3
作者：
M. Heng;S. Allen;D. Chase
通讯作者：
D. Chase
DOI：
10.1016/0022-202x(89)90193-0
发表时间：
1989-05
期刊：
The Journal of investigative dermatology
影响因子：
--
作者：
Kay H. Singer;Debbi T. Tuck;Hugh A. Sampson;Russell P. Hall
通讯作者：
Kay H. Singer;Debbi T. Tuck;Hugh A. Sampson;Russell P. Hall
干扰素-γ 在淋巴细胞皮肤运输中的作用，重点是分子和细胞粘附事件。
影响因子：
--
作者：
Nickoloff,BJ
通讯作者：
Nickoloff,BJ