Genetic mapping of the female mimic morph locus in the ruff.
Genetic mapping of the female mimic morph locus in the ruff.
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DOI：
10.1186/1471-2156-14-109
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发表时间：
2013-11-20
期刊：
影响因子：
2.9
通讯作者：
Lank DB
中科院分区：
文献类型：
--
作者：
Farrell LL;Burke T;Slate J;McRae SB;Lank DB
鲁夫斯（鸟纲：Philomachus pugnax）具有雄性交配行为的遗传多态性，导致三种永久性的雄性生殖形态：（i）领地性“独立者”，（ii）非领地性“卫星”，以及（iii）模仿雌性的“费德斯”。先前已证明，发育成独立或卫星变体是由于卫星基因座的单基因座、双等位基因常染色体孟德尔遗传模式所致。在这里，我们使用连锁分析来绘制 Faeder 基因座的染色体位置，该基因座控制 Faeder 变体的发育，并假设与其他鸟类共享同线性，并得出有关候选基因的进一步结论。 Faeder 基因座的分离数据来自包含 64 个多代家族的圈养谱系 (N = 381)。没有证据表明 Faeder 基因座与卫星基因座连锁，但它与微卫星标记 Ppu020 连锁。对鸡 (Gallus gallus) 和斑马雀 (Taeniopygia guttata) 基因组的颈毛微卫星标记进行比较作图，将 Ppu020 和 Faeder 基因座置于 11 号染色体的一个区域，该区域包括 Melanocortin-1 受体 (MC1R) 基因，该基因调节许多鸟类和其他脊椎动物的颜色多态性。基于黑色素的颜色随着颈毛和其他物种的生活史策略而变化，因此 MC1R 基因是在替代雄性形态决定中发挥作用的有力候选基因。两个不连锁的基因座似乎控制着颈毛的行为发育。 Faeder 基因座与 Ppu020 连锁，假设同线性，Ppu020 位于鸟类 11 号染色体上。MC1R 是参与颈毛替代雄性形态决定的候选基因。
Ruffs (Aves: Philomachus pugnax) possess a genetic polymorphism for male mating behaviour resulting in three permanent alternative male reproductive morphs: (i) territorial ‘Independents’, (ii) non-territorial ‘Satellites’, and (iii) female-mimicking ‘Faeders’. Development into independent or satellite morphs has previously been shown to be due to a single-locus, two-allele autosomal Mendelian mode of inheritance at the Satellite locus. Here, we use linkage analysis to map the chromosomal location of the Faeder locus, which controls development into the Faeder morph, and draw further conclusions about candidate genes, assuming shared synteny with other birds. Segregation data on the Faeder locus were obtained from captive-bred pedigrees comprising 64 multi-generation families (N = 381). There was no evidence that the Faeder locus was linked to the Satellite locus, but it was linked with microsatellite marker Ppu020. Comparative mapping of ruff microsatellite markers against the chicken (Gallus gallus) and zebra finch (Taeniopygia guttata) genomes places the Ppu020 and Faeder loci on a region of chromosome 11 that includes the Melanocortin-1 receptor (MC1R) gene, which regulates colour polymorphisms in numerous birds and other vertebrates. Melanin-based colouration varies with life-history strategies in ruffs and other species, thus the MC1R gene is a strong candidate to play a role in alternative male morph determination. Two unlinked loci appear to control behavioural development in ruffs. The Faeder locus is linked to Ppu020, which, assuming synteny, is located on avian chromosome 11. MC1R is a candidate gene involved in alternative male morph determination in ruffs.
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