SARS-CoV-2: Possible recombination and emergence of potentially more virulent strains.
SARS-CoV-2: Possible recombination and emergence of potentially more virulent strains.
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SARS-COV-2：可能重组和潜在毒性菌株的出现。
DOI：
10.1371/journal.pone.0251368
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发表时间：
2021
期刊：
影响因子：
3.7
通讯作者：
Al-Mulla F
中科院分区：
文献类型：
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作者：
Haddad D;John SE;Mohammad A;Hammad MM;Hebbar P;Channanath A;Nizam R;Al-Qabandi S;Al Madhoun A;Alshukry A;Ali H;Thanaraj TA;Al-Mulla F
COVID-19 is challenging healthcare preparedness, world economies, and livelihoods. The infection and death rates associated with this pandemic are strikingly variable in different countries. To elucidate this discrepancy, we analyzed 2431 early spread SARS-CoV-2 sequences from GISAID. We estimated continental-wise admixture proportions, assessed haplotype block estimation, and tested for the presence or absence of strains’ recombination. Herein, we identified 1010 unique missense mutations and seven different SARS-CoV-2 clusters. In samples from Asia, a small haplotype block was identified, whereas samples from Europe and North America harbored large and different haplotype blocks with nonsynonymous variants. Variant frequency and linkage disequilibrium varied among continents, especially in North America. Recombination between different strains was only observed in North American and European sequences. In addition, we structurally modelled the two most common mutations, Spike_D614G and Nsp12_P314L, which suggested that these linked mutations may enhance viral entry and replication, respectively. Overall, we propose that genomic recombination between different strains may contribute to SARS-CoV-2 virulence and COVID-19 severity and may present additional challenges for current treatment regimens and countermeasures. Furthermore, our study provides a possible explanation for the substantial second wave of COVID-19 presented with higher infection and death rates in many countries.
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影响因子：
9.2
作者：
Chang CC;Chow CC;Tellier LC;Vattikuti S;Purcell SM;Lee JJ
通讯作者：
Lee JJ
影响因子：
3.9
作者：
Page AJ;Taylor B;Delaney AJ;Soares J;Seemann T;Keane JA;Harris SR
通讯作者：
Harris SR
DOI：
10.1093/bioinformatics/btp348
发表时间：
2009-08-01
期刊：
Bioinformatics (Oxford, England)
影响因子：
--
作者：
Capella-Gutiérrez S;Silla-Martínez JM;Gabaldón T
通讯作者：
Gabaldón T
影响因子：
10.7
作者：
Katoh K;Standley DM
通讯作者：
Standley DM
DOI：
10.1007/978-1-4939-6622-6_17
发表时间：
2017-01-01
期刊：
BIOINFORMATICS, VOL I: DATA, SEQUENCE ANALYSIS, AND EVOLUTION, 2ND EDITION
影响因子：
--
作者：
Martin, Darren P.;Murrell, Ben;Muhire, Brejnev
通讯作者：
Muhire, Brejnev